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The effect of Ficus carica latex on 7, 12-dimethylbenz (a) anthracene-induced breast cancer in rats

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Year: 2018
COI code: JR_AJP-8-4_001
Paper Language: English

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Authors The effect of Ficus carica latex on 7, 12-dimethylbenz (a) anthracene-induced breast cancer in rats

  Mahnoosh Fatemi - Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
  Fereshte Ghandehari - Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

Abstract:

Objective: In traditional medicine, Ficus carica (also known as fig) latex is recognized as a remedy with various therapeutic effects. Recently, in vitro studies have reported the anticancer effect of this latex on cancer cell lines. This study evaluated the effect of this latex on breast cancer growth, hematological parameters, and histopathology in rats. Materials and Methods: Twenty-four female rats were randomly divided into 3 groups. In cancerous group, 0.5 ml 7, 12-dimethylbenz (a) anthracene was injected to nipple for breast cancer induction. The control group received sesame oil at the same volume through similar route. In fig latex treated group (Fle), breast cancer was induced and then 0.5 ml of fig latex was intratumorally injected on a daily basis for 4 weeks. Tumor size was measured at the 2nd, 4th and 6th weeks of the experiment. Blood samples were used for investigation of the hematological parameters and livers, kidneys and tumor tissues were removed for histopathological analysis. Results: The tumor size in Fle group was significantly decreased compared to the cancerous group. Haematocrit, hemoglobin, RBC and their indices were significantly decreased, whereas platelet, leukocyte and white blood cell numbers were significantly increased in cancerous group compared to the control group. There were no changes in these parameters in the Fle group compared to the control group. There were severe pathological changes in the livers and kidneys of cancerous group, but not in Fle group. Conclusion: These results suggest that fig latex could decrease tumor growth without having any adverse effect on hematological and histological factors. However, further investigation is required in this field.

Keywords:

Breast Cancer, Ficus carica latex, hematological parameters, Histopathology, Rat

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COI code: JR_AJP-8-4_001

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Fatemi, Mahnoosh & Fereshte Ghandehari, 2018, The effect of Ficus carica latex on 7, 12-dimethylbenz (a) anthracene-induced breast cancer in rats, Avicenna Journal of Phytomedicine 8 (4), https://www.civilica.com/Paper-JR_AJP-JR_AJP-8-4_001.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Fatemi, Mahnoosh & Fereshte Ghandehari, 2018)
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Type: Azad University
Paper No.: 397
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