Published in: فصلنامه طب دامی ایران، دوره: 14، شماره: 1
COI code: JR_IJVM-14-1_007
Paper Language: English
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Authors مطالعه تجربي اثرات سم عقرب مزوبوتوس اوپئوس بر غلظت پلاسمايي هورمون هاي متابوليك و گلوكز در موش صحراييMohammad Razi Jalali - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz,Iran
Seyedeh Missagh Jalali - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Hedieh Jafari - Department of Venomous Animals and Toxins, Razi Vaccine and Serum Research Institute, Ahvaz, Iran
Mohammad Babakhan - Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Abstract:BACKGROUND: Mesobuthus eupeus is an indigenous scorpion species in Southwest Iran which is respon- sible for the majority of scorpion sting cases in Khuzestan province. OBJECTIVES: The effects of M. eupeus venom were investigated on the chief metabolic hormones in rats. METHODS: A total of 45 Albino male rats were divided into 3 equal groups: group 1 (control): 0.5 ml normal saline was administered intraperitoneally (IP); group 2 and 3: M. eupeus venom was administered with a dose of 1 and 2 mg/kg IP, respectively. Sampling was performed at 8, 24, and 48 hours after venom/ saline injection. RESULTS: The levels of thyroxine (T4) and triiodothyronine (T3) were significantly lower in both venom receiving groups (groups 2 and 3) than in the control group, dose-dependently, at all sampling times. There was a significant decrease in insulin level in both intoxicated groups compared to the control group at all sampling times. Glucagon, cortisol and subsequently glucose concentrations were significantly increased in both groups receiving the venom (groups 2 and 3) compared to the control group at 8 and 24 hours following envenomation. CONCLUSIONS: The findings of this study indicate that M. eupeus venom can suppress the secretion of essential metabolic hormones including T3, T4, and insulin and stimulate the release of glucagon, and cor- tisol, leading to hyperglycemia.
Keywords:Cortisol, endocrine system, insulin, Mesobuthus eupeus, Scorpion
COI code: JR_IJVM-14-1_007
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Razi Jalali, Mohammad; Seyedeh Missagh Jalali; Hedieh Jafari & Mohammad Babakhan, 2020, مطالعه تجربي اثرات سم عقرب مزوبوتوس اوپئوس بر غلظت پلاسمايي هورمون هاي متابوليك و گلوكز در موش صحرايي, Iranian Journal of Veterinary Medicine 14 (1), https://www.civilica.com/Paper-JR_IJVM-JR_IJVM-14-1_007.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Razi Jalali, Mohammad; Seyedeh Missagh Jalali; Hedieh Jafari & Mohammad Babakhan, 2020)
Second and more: (Razi Jalali; Jalali; Jafari & Babakhan, 2020)
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Type: state university
Paper No.: 13712
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