Published in: مجله علوم نانو، دوره: 1، شماره: 3
COI code: JR_NAMJ-1-3_007
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors The effect of gold nanoparticle on renal function in ratsMonir Doudi - Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
Mahbubeh Setorki - Department of Biology Izeh Branch, Islamic Azad University, Izeh, Iran
Abstract:Objective(s): This study aimed to address the gold nanoparticle(GNP)-dose and exposure duration effect on the kidney function of rats: in vivo. Materials and Methods: A total of 32 healthy male Wistar rats were used in this study. Animals were randomly divided into groups, three GNP-treated groups and control group. Group 1, 2 and 3 received. /5 cc of solution containing 5, 10,100 ppm Au via IP injection for 7 successive days, respectively. The control group was treated with 0.5% normal saline. Several biochemical parameters such as BUN (blood urea nitrogen), creatine and uric acid were evaluated at various time points (7 and 14 days). After 14 days, the tissue of kidney was collected and investigated. Results: There was no significant difference between the control and the intervention group regarding the amount of creatine-BUN and uric acid. The amount of creatine-BUN and uric acid showed increase in all the groups [except group1 (creatine) and group 2 (uric acid)] in the 7 and 14 days after intervention compared to the control group, but this difference was not significant. Results of histopatological tissue kidney showed: in group 1 and 3, complete destruction of the proximal tubules and distal cortical, in group 2, almost complete destruction of proximal tubules and distal. Conclusions: The induced histological alterations might be an indication of injured renal tubules due to GNPs toxicity that become unable to deal with the accumulated residues resulting from metabolic and structural disturbances caused by these NPs
Keywords:gold nanoparticle (GNP), Urea, Rats, Renal function
COI code: JR_NAMJ-1-3_007
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Doudi, Monir & Mahbubeh Setorki, 2014, The effect of gold nanoparticle on renal function in rats, Nanomedicine Journal 1 (3), https://www.civilica.com/Paper-JR_NAMJ-JR_NAMJ-1-3_007.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Doudi, Monir & Mahbubeh Setorki, 2014)
Second and more: (Doudi & Setorki, 2014)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Azad University
Paper No.: 397
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Overview of Quadcopter Design, Control and Application
- A review of recent advances in biodegradable polymers in tissue engineering
- Investigating the effect of employees happiness in the workplace in Management evolution
- Skimmers Separators of oil pollutants from the sea
- Single Cell Proteins: A novelty in Food Technology
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.