Published in: مجله علوم نانو، دوره: 7، شماره: 2
COI code: JR_NAMJ-7-2_007
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors A novel three-dimensional printing of electroconductive scaffolds for bone cancer therapy applicationMarjan Monshi - Advanced Materials Research Centre, Department of Materials Science and Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran
Saeid Esmaeili - Mechanical Engineering Department, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr, Iran
Amin Kolooshani - Mechanical Engineering Department, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr, Iran
Bahareh Kamyab Moghadas - Department of Chemical Engineering, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Abstract:Objective(s): Tissue engineering aims to achieve a tissue, which has highly interconnected porous microstructure concurrent with appropriate mechanical and biological properties. Materials and Methods: Therefore, the microstructure scaffolds are of great importance in this field. In the present study, an electroconductive poly-lactic acid (EC-PLA) filament used to fabricate a porous bone scaffold. For scaffolds model designed, solid-work software was used. Then, the designed modeled was transferred to simplify 3D to laminated with its G-Code file for fused deposition modeling (FDM) printer to create a scaffold with porosity around 65-75%. Two different shapes were designed and fabricated (cylindrical and cubic shape). The samples were coated with hydroxyapatite (HA) nanoparticle to enhance its chemical stability. In this study, the X-ray diffraction (XRD) confirmed that the EC-PLA is non-crystalized and scanning electron microscopy (SEM) used to present the apatite formation on the surface of porous scaffolds. The compression test, fracture toughness, and hardness were measured. The biological response in the physiological saline was performed to determine the rate of degradation of EC-PLA in phosphate buffer saline (PBS) and the apatite formation in the simulated body fluid (SBF) after 14 days. Results: Finally, the biocompatibility of the porous architecture was monitored using human gum (HuGu) cells. The ABAQUS modeling simulation was used to compare the experimental and analytical results. The obtained results showed that by applying force to both cylindrical and cubic scaffold, the Von Mises Stress (VMS) could withstand the scaffold mentioned above at 9.7-11 MPa. Conclusion: Therefore, it can be concluded that prepared porous scaffolds have a high potential in bone tissue engineering and probably the treatment of tumor-related bone defects as photothermal therapy. The porous EC-PLA scaffold was successfully fabricated and showed appropriate compressive strength (39.14 MPa), with controllable porosity of 60-70 %, which is a suitable candidate for replacing in bone tissues.
Keywords:Cell culture, Electroconductive Poly lacticacid, Scaffold, Tissue engineering
COI code: JR_NAMJ-7-2_007
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Monshi, Marjan; Saeid Esmaeili; Amin Kolooshani & Bahareh Kamyab Moghadas, 2020, A novel three-dimensional printing of electroconductive scaffolds for bone cancer therapy application, Nanomedicine Journal 7 (2), https://www.civilica.com/Paper-JR_NAMJ-JR_NAMJ-7-2_007.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Monshi, Marjan; Saeid Esmaeili; Amin Kolooshani & Bahareh Kamyab Moghadas, 2020)
Second and more: (Monshi; Esmaeili; Kolooshani & Moghadas, 2020)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Azad University
Paper No.: 8366
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Decrease of COD Wastewater Automotive by Using Sludge Prodused by Process
- Influence of Protective Oil on Properties of Automotive Phosphate Layer
- Comparison of Water Borne and Solvent Base Paints Curing
- Optimizing the Coating Weight in Iran Khodro Paint Shop
- Research on Effective Parameters for Decrease Amount of Sludge at Phosphate Bath of Automotive Industry
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.