Seroprevalence of Epstein-Barr virus (EBV) in HIV infected patients

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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ACPLMED20_017

تاریخ نمایه سازی: 29 تیر 1398

Abstract:

Objectives: Patients with AIDS are at risk for opportunistic infections such as Epstein-Barr virus (EBV) infection. The aim of this study was to determine the prevalence of EBV infection in HIV-infected patients and compare it with healthy individuals in Hamadan Province in the west of Iran. Methods: In a case-control study, 61 HIV-infected patients and 62 healthy individuals, were enrolled. IgM and IgG viral capsid antigens (VCA) antibodies for EBV was measured by chemiluminescent immunoassay system and CD4 cell count was measured by flowcytometry method. Data were analyzed using SPSS (version 16). Results: All HIV-infected patients (100%) had positive EBV IgG-VCA antibody; while, in the controls, 57(91.9%) were positive (P=0.02). There was no statistically significant relationship between CD4 cell counts and the prevalence of EBV infection in HIV-infected patients (P=0.4). However, there was statistically significant relationship between the reducing of CD4 cell counts and rising of EBV IgG-VCA antibody titer (P=0.001). Moreover, there was no significant association between EBV IgG-VCA antibody with age, sex and anti-retrovirus therapy in HIV-infected patients (P> 0.05). Conclusion: The high prevalence of EBV infection in HIV-infected patients, especially in the patients with a low CD4 count, could lead to high risk of EBV complications.

Authors

Hamid Reza Ghasemi Basir

Department of Pathology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Fariba Keramat

Department of Infectious Diseases, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran