Effects of Curcumin-Loaded Chitosan Nanoparticles on Intra Ocular Pressure

Purpose: Reactive oxygen species such as superoxide, hydrogen peroxide and hydroxyl radicals are inducers of oxidative stress. Curcumin, as a strong scavenger, has important role in preventing ocular disease such as glaucoma. Methods: After preparation of chitosan nanoparticles, curcumin was added into chitosan solution for theformulation of drug loaded NPs. IOP reducing efficiency of curcumin loaded nanoparticles was assessed by using a tonometer after administration of CUR loaded nanoparticles on the corneal surface of left eyes of experimental animals. Results: Our results showed that use of CUR loaded nanoparticles decreased the intra ocular pressure (IOP)effects significantly in comparison with CUR and chitosan nanoparticles alone (p<0.05). Conclusion: Taken together, use of Curcumin-loaded chitosan (CS) nanoparticles enhanced reduction of IOP which can be beneficial in treatment of glucoma.