Synthesis of3-(1H-1-imidazolyl)-2-methyl-4-chromanoneas a pharmaceutical composition defaultby α-bromo-2-hydroxy acetophenone

The maximum range antifungal drugs are relatively limited impact, or due to toxicity, The lack of the potential for systemic use . Therefore, this study With the goal gain of antifungal With a wide And fewer drug interactions, seems to be necessary. Derivatives of 1-(2-hydroxy-phenyl)-2-(1H-1- Imidazolyl)-1-ethanol Undergo cycloaddition reaction is the whit Acetaldehyde And compound 3-(1H-1-Imidazolyl)-2-methyl-4-chromanone is prepared as azole drugs whit the potential effect of fungicide . Chemical structure built determined and confirmed By infrared spectroscopy, nuclear magnetic resonance and mass spectrometry . In order to differentiate and identify the trans Stereoisomers Between the two groups imidazole and methyl in the ring chromanone was used of the 1H NMR spectroscopy.

Keywords:

Imidazolyl , chromanone , antifungal