Her-2/neu expression in esophageal cancer patient in Afzalipour hospital: during 2009 to 2016

Background: Esophageal squamous cell carcinoma (ESCC) and Adenocarcinoma (EAC) are two most frequent types of esophageal cancer which have poor prognosis and highmorbidity rates. HER-2 is a member of the epidermal growth factor receptors which its overexpression occure in 10–30% of gastric/gastroesophageal cancers.Objectives: To determine the incidence of human epidermal growth factor receptor 2 (HER2) over expression in oesophageal cancer subtypes.Materials/Patients and Methods: In this cross-sectional study 103 admissible ESCC and EAC cases of Kerman Afzalipour hospital from 2009 to 2016 were investigated. HER2overexpression was evaluated using immunohistochemistry (IHC) in formalin-fixed paraffin-embedded tissue blocks Results: The mean age was around 57 and 67 in ESCC and EAC patients, respectively. The number of ESCC cases was almost twice the EAC ones. Esophageal carcinoma patients were classified as: 17.5% well differentiated (Grade 1), 67% moderately differentiated (Grade 2), 15.5% poorly differentiated (Grade 3). Loco regional lymph node metastasis was observed in 69 patients (67%). HER-2/neu expression was +3 in 22.3%, 2+ in 45.6%, 1+ in 24.3% and 0 in 7.8% of evaluated tumors.Conclusion: In this studied patient population, Squamous cell carcinoma had a higher prevalence compared with adenocarcinoma. HER-2 expression was significantly higher inESCC than EAC samples. There were not any difference between HER2 expression and lymph node involvement in ESCC or EAC samples

Keywords:

Esophageal cancer , HER-2 , Immunohistochemistry , Squamous cell carcinoma , Adenocarcinoma , Overexpression