Evaluation of expression of miR-223 in serum of patients with a gastric cancer undergoing surgery or chemotherapy

Introduction & Aim: Gastric cancer (GC) is one of the four most commonly diagnosed cancers in the world, with men twice as likely as women. GC is the most common cancer in men in Iran. MicroRNAs (miR) are a group of small non-coding and single-stranded RNAs of 18 to 25 nucleotides. The study of microRNAs is one of the new ways to detect cancer. In this study, for the first time in Iran, expression of miR-223 in the serum of patients with gastric cancer who had had surgery or chemotherapy was compared. Methods: The study was conducted in 39 patients with gastric cancer who visited the Reza Radiotherapy and Oncology Center in Mashhad. Their demographic information was collected and their serum levels of miR-223 were measured using the Real-time PCR technique and the association between the expression of this microRNA with Surgery or Chemotherapy was compared. The results were analyzed by the SPSS software. Results: There was no significant difference relationship between the expression of miR-223 in the serum of patients with gastric cancer, having the same grade and stage, who has had surgery or chemotherapy. Conclusion: The results of this study show that , although the expression of miR-223 has been increased in surgery and chemotherapy groups compared with their respectualy control but there was no significant relationship between miR-223 expression in surgery and chemotherapy.

Keywords:

Gastric Cancer , miR-223 , Serum , Surgery , Chemotherapy