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NPAS2 gene expression in gastric cancer

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Year: 2018
COI code: CANCERMED04_072
Paper Language: English

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Authors NPAS2 gene expression in gastric cancer

  Negar Haghpanah - Department of Biology, University Campus2, University of Guilan, Rasht, Iran
  Zivar Salehi - Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran
  Mohammadjavad Mehdipour - Research Center for Gastroenterology and Liver Diseases, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
  Soheila Talesh Sasani - Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

Abstract:

The circadian clock refers to the inherent biological rhythm of an organism, which, is accurately regulated by numerous clock genes. It has been reported that the abnormal expression of clock genes is ubiquitous in common malignant tumors. Circadian clock regulation in mammals is controlled by feedback loops of a set of circadian genes. One of these circadian genes, NPAS2, encodes for a member of the bHLH-PAS class of transcription factors and is expressed in the forebrain and in some peripheral organs. NPAS2, an essential component of the feedback loop, dimerizes with ARNTL, another core circadian protein, and binds to DNA sequences to activate gene transcription. NPAS2/ ARNTL heterodimer controls the transcription of two other circadian genes PER and CRY, which are required for maintaining biologic rhythms in many organisms. It has been shown that the NPAS2 is involved in cell proliferation, DNA damage repair and malignant transformation. The objective of this study was to study the relative expression level of NPAS2 in gastric cancer compare with normal gastric mucosa. RNA was extracted from 30 resected tumor and 30 normal gastric specimens. The expression levels of NPAS2 mRNA were determined by qRT-PCR. The results showed that there was a significant difference in the expression of NPAS2 gene between patient and control groups (P<0.05). In conclusion, our findings in this research suggest that the altered gene expression in NPAS2 gene is related to gastric tumor formation. However, further studies with a larger sample size are required to verify these results.

Keywords:

Gastric cancer, NPAS2, Circadian rhythm

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Haghpanah, Negar; Zivar Salehi; Mohammadjavad Mehdipour & Soheila Talesh Sasani, 2018, NPAS2 gene expression in gastric cancer, 4th International Congress of Gastrointestinal Cancer, تهران, مركز تحقيقات سرطان بيمارستان شهداي تجريش, https://www.civilica.com/Paper-CANCERMED04-CANCERMED04_072.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Haghpanah, Negar; Zivar Salehi; Mohammadjavad Mehdipour & Soheila Talesh Sasani, 2018)
Second and more: (Haghpanah; Salehi; Mehdipour & Talesh Sasani, 2018)
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Type: state university
Paper No.: 11477
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