The Importance of Recognizing Binding Sites and Introducing Methods for Identification of them
Publish place: 14th Conference on Biophysical Chemistry
Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CBC15_008
تاریخ نمایه سازی: 29 خرداد 1398
Abstract:
Determination of binding site is important for understanding the function of biological macromolecules. Understanding the specific binding site of the substrate to the enzyme, which is called active site, is essential for investigating the mechanism of the enzyme. It is important to recognize the binding site of the hormone in the receptor, drug binding site in proteins and nucleic acids, etc. from different perspectives. In order to design new drugs, it is necessary to determine the drugs binding site in the macromolecule. There are several ways to investigate binding sites. Using X-ray and NMR are appropriate for this purpose. Fluorescence, Raman and IR methods can also be used. The use of molecules with a specific binding site is an indirect method for determining the binding site. For well-known structures that have PDB files, molecular docking techniques and molecular dynamics simulations it can be used.
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Authors
Mohammad Reza Housaindokht
Department of Chemistry, Faculty of Science, Ferdowsi University of Mashhad, Iran