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Assessment of boron nitride fullerenes as the drug delivery vehicles of Ifosfamide

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Year: 2018
COI code: CBC15_019
Paper Language: English

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Authors Assessment of boron nitride fullerenes as the drug delivery vehicles of Ifosfamide

  Elham Tazikeh Lemeshi - Department of Chemistry, Gorgan Branch, Islamic Azad University, Gorgan, Iran
  Alireza soltani - Golestan Rheumatology Research Center, Golestan University of Medical Science,Gorgan, Iran
Masoud Bezi Javan - Physics Department, Faculty of Sciences, Golestan University, Gorgan, Iran

Abstract:

Osteosarcoma is a cancerous tumor that starts in the bones. The therapeutic activity of drugs is limited by their severe drug-related toxicities; therefore, a therapeutic approach which is less toxic and highly effective in tumor cell is of utmost importance. In this study, we considered density functional theory (DFT) calculations upon the adsorption of Ifosfamide (IFO) as a antitumor agent on a series of pure B12N12 and carbon-doped boron nitride including B12N6C6 and B6N6C12 fullerenes for both vacuum and solvent (water) environment conditions by means of PBE-1 and M06-2X functionals and 6-311+G (d,p) basis set. Our study successfully demonstrated that the adsorption of antitumor agent upon the fullerenes will increase the polarizability of boron nitride fullerenes in comparison with C60 fullerene, but on the other hand, the energy of the interaction of IFO with B6N6C12 is greater, which can reduce its release rate from the system.

Keywords:

Osteosarcoma, Density Functional Theory (DFT), Ifosfamide

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COI code: CBC15_019

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Tazikeh Lemeshi, Elham; Alireza soltani & Masoud Bezi Javan, 2018, Assessment of boron nitride fullerenes as the drug delivery vehicles of Ifosfamide, 14th Conference on Biophysical Chemistry, گرگان, دانشگاه آزاد اسلامي واحد گرگان -انجمن بيوشيمي فيزيك ايران, https://www.civilica.com/Paper-CBC15-CBC15_019.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Tazikeh Lemeshi, Elham; Alireza soltani & Masoud Bezi Javan, 2018)
Second and more: (Tazikeh Lemeshi; soltani & Bezi Javan, 2018)
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Type: Azad University
Paper No.: 2547
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