Determination of diclofenac in real samples by a new two liquid-phase microextraction method considering green chemistry aspects

Publish Year: 1398
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

CBGCONF06_250

تاریخ نمایه سازی: 28 بهمن 1398

Abstract:

In the present research, a new, speed, inexpensive and very simple preconcentration and sample preparation method based on two liquid-phase microextraction was used for the extraction of trace amounts of diclofenac in real water samples prior to UV-Vis spectrophotmeter. The parameters influencing the extraction efficiencies including the kind of extracting solvent, microextraction time, the volume of the aqueous sample solution (donor phase), the volume of extraction solvent (acceptor phase), the stirring speed, the effects of pH and salt were optimized. Under the optimal conditions, the obtained enrichment factor is above 48. By plotting absorbance of the standard solutions versus various concentrations of the analyte, calibration curve is obtained which show that the linear ranges of 0.003 -1.5 µg mL-1 with correlation coefficient (r) of 0.9980 for diclofenac. The precision of the method was calculated as relative standard deviation (RSD %, n=5) in three different concentrations and were 5.6. The limit of detection (LOD) and also, the the limit of quantitation (LOQ) were calculated theoritically and the obtained values were 0.0009 and 0.003, respectively. Finally, the proposed microextraction method was used for the extraction of the analyte from environmental water samples and the calculated relative recoveries were all above than % 89.

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Authors

Fatemeh Abedi Gonabad

Department of Chemistry, Quchan Branch, Islamic Azad University, Quchan, Iran.

Farideh Mofazzeli

Department of Chemistry, Quchan Branch, Islamic Azad University, Quchan, Iran.