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Nanofibers fabricated from graphene oxide and methotrexate to examine the melanoma cells mortality rate

Credit to Download: 1 | Page Numbers 9 | Abstract Views: 58
Year: 2020
COI code: CCES09_012
Paper Language: English

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Authors Nanofibers fabricated from graphene oxide and methotrexate to examine the melanoma cells mortality rate

  Maryam Nazari - Faculty of Chemistry, Razi University, Kermanshah, Iran
  Soheila Kashanian - Faculty of Chemistry, Razi University, Kermanshah, Iran- Nano Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
  Hossein Zhaleh - Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  Tayebeh Noori - Faculty of Chemistry, Razi University, Kermanshah, Iran
  Elham Arkan - Nano Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

Abstract:

The graphene oxide-based nanomaterials application has recently attracted severalresearchers in drug delivery field; because of their valuable properties. A drug carrier systemof the nanofibers based on the electrospinning of graphene oxide, chitosan, polyvinyl alcohol,and polyethylene oxide has been developed to deliver and monitor the drug release by theeffect on melanoma cancer cells. Fourier transform infrared spectroscopy, and scanningelectron microscopy confirmed the successful drug loading. Cellular toxicity assay exhibiteddrug loaded-graphene oxide nanofibers are biocompatible having cell viability greater than80% for melanoma cell line. In vitro dissolution studies using cell line showed that most ofthe drug was released in 0–72 h from drug loaded nanofibers and, hence, these modifiednanofibers have the potential for drug delivery purposes.

Keywords:

Graphene oxide; Chitosan; Nanofiber; Drug delivery; Methotrexate

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Nazari, Maryam; Soheila Kashanian; Hossein Zhaleh; Tayebeh Noori & Elham Arkan, 2020, Nanofibers fabricated from graphene oxide and methotrexate to examine the melanoma cells mortality rate, 9th National Conference on Modern Research in Chemical Science and Engineering, بابل, موسسه علمي تحقيقاتي كومه علم آوران دانش, https://www.civilica.com/Paper-CCES09-CCES09_012.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Nazari, Maryam; Soheila Kashanian; Hossein Zhaleh; Tayebeh Noori & Elham Arkan, 2020)
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Type: state university
Paper No.: 7854
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