Acute Lymphoproliferative leukemia

مقدمه: Introduction:Acute lymphoproliferative leukemia (ALL) is malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells.In most cases, the cause is unknown.Genetic and Environmental risk factors,an abnormal immune response to an infection may be trigger.The underlying mechanism involves multiple genetic mutations that results in rapid cell division.The excessive immature lymphocytes in the bone marrow interfere with the product of other cells.Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain• معرفی بیمار: Case report:A 77 years old woman refered with pain in her abdoman associated with nausea and vomiting.icteric skin and some signs of ecchymosis on her leg was noticable.past medical history included;HTN and DMdue to cholestatic hyperbilirubinemia in her tests,biliary obstruction became susceptible diagnose.Although gallbladder contraction was seen in MRCT,but there wasn any signs of splenomegaly,limphadenopathy or any extrinsic pressure on the area.also there wasn evidence of obstruction.according Introduction:Acute lymphoproliferative leukemia (ALL) is malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells.In most cases, the cause is unknown.Genetic and Environmental risk factors,an abnormal immune response to an infection may be trigger.The underlying mechanism involves multiple genetic mutations that results in rapid cell division.The excessive immature lymphocytes in the bone marrow interfere with the product of other cells.Symptoms may include feeling tired, pale skin color, fever, easy bleeding or bruising, enlarged lymph nodes, or bone pain to her pancytopenia and increased RDW and hepatic enzymes,hematology consult required.bone marrow biopsy was done and section of BMB specimen showed marrow spaces diffusely infiltrated and occupied by lymphoid like cells with large nuclei and high mitotic activity.normal marrow cells extremely were decreased because of the neoplastic cells infiltration.hypercellular bonemarrow was compatible with lymphoproliferative disorder.treatments such asEndoxan,prednisolone and vincristine started for her and related to well response to the corticosteroid therapy,ALL was the final diagnose. بحث نتیجه گیری: Result:Signs and symptoms of acute lymphocytic leukemia may include:Bleeding from the gumsBone, pain,Fever,Frequent infections,Frequent or severe nose bleeds Lumps caused by swollen lymph nodes in and around the neck, under arm, abdomen or groin,Pale skin,Shortness of breathWeakness and fatiguealthough these are common symptoms of ALL,the patient had been refered with rare symptome of hyperbilirubinemia associated with pancytopenia

Keywords:

ALL-Hyperbilirubinemia-pancytopenia