Facile diastereoselective sonochemical synthesis of isoxazolidines catalyzed by Fe3O4-L-proline nanoparticles as a magnetic catalyst

Fe3O4-L-proline nanoparticles as a magnetic agent catalyzed the synthesis of isoxazolidines and spiroisoxazolidines via the one-pot three-component condensation reaction between N-arylhyroxylamine, arylaldehyde, isatines and α,β-unsaturated aldehyde under ultrasound irradiation. The application of ultrasonic irradiation improved the yields and reduced the reaction times. The use of Fe3O4-L-proline catalyst is feasible because of its easy preparation, easy handling, stability, easy recovery, reusability, good activity and eco-friendly.

Keywords:

isoxazolidines , sonochemical , L-proline , 1 , 3-dipolar cycloadditions