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CTLA-4 -49A/G Gene Expression In Patients With Visceral Lishmaniosis

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Year: 2012
COI code: CIGS12_0073
Paper Language: English

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Authors CTLA-4 -49A/G Gene Expression In Patients With Visceral Lishmaniosis

  SH Abdolzade - Tabriz University of Medical Sciences
   Babaloo - Tabriz University of Medical Sciences
  Z Rajaiim - Tabriz University of Medical Sciences


Background&:The diseases caused by Leishmania parasites range from coetaneous leishmaniasis (CL) characterized by self-resolving local coetaneous lesions to the more serious visceral leishmaniasis (VL), which is potentially fatal.VL results from infection with Leishmania donovani or Leishmania infantum, and is usually fatal if left untreated following clinical diagnosis. Key proinflammatory (Th1) cytokines required are IL- 12, IFNγ, and TNF, lymphotoxin (LT), for efficient immune responses against lishmanie infection through Th1 and macrophage activation. Aims: Cytolytic T lymphocyte antigen -4 (CTLA-4) is an inhibitory receptor expressed by activated and regulatory T cells. The single nucleotide polymorphism (SNP) - 49 A/G of the CTLA-4 gene alters intracellular distribution of CTLA-4, interleukin-2 production, and, as a consequence, T-cell proliferation. The aim of this study was to analyze the only coding SNP CTLA-4 -49 A/G polymorphism in patients with viseral lishmaniosis.


CTLA-4- Visceral Lishmaniosis- Immune response

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COI code: CIGS12_0073

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Abdolzade, SH; Babaloo & Z Rajaiim, 2012, CTLA-4 -49A/G Gene Expression In Patients With Visceral Lishmaniosis, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Abdolzade, SH; Babaloo & Z Rajaiim, 2012)
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The University/Research Center Information:
Type: Medical University
Paper No.: 2414
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