Published in: 12th Congress of Iranian Genetics Society
COI code: CIGS12_0222
Paper Language: English
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Authors Methylation changes in glutation S-transferase P1(GSTP1) gene promoter in human breast cancer and it’s relation to tumor prognosis.Shohreh Alizadeh Shargh - Department of Medical sciences,Health institute,Chalous İslamic Azad university,Chalous,Iran - Department of Medical Genetic & Biology,Health Institute of 9 Eylul university,Izmir.Turkey.
Shahrzad Soleimani - Department of Medical sciences,Health institute,Chalous İslamic Azad university,Chalous,Iran
Hamidreza Yazdi - Department of Medical Science, Biotechnology consultor & manenger, Fragen Pouyesh Company headmaster,Tehran, Iran
Abstract:Glutation S-transferase P1 (GSTP1) gene methylation in promoter CpG islands has been described as a specific biomarker for many types of cancer including breast cancer as a tumor suppressor gene . At presents study we found the GSTP1 gene promoter to be methylated in breast cancer tissues.To study the effect of sequence variation on hypermethylated GSTP1 promoter in cancer tissues and non methylated one in normal tissues, we analyzed the cytosine methylation status as epigenetic changes in 50 tumors from patient’s with breast cancer and 50 normal breast tissues that taken from the same breast tumor’s adjacent region.In order to study the promoter methylation status for GSTP1 gene in breast cancer, 40 CpG sites [nucleotide(nt) 197,190,187,185,183,182,176,162,155,152,148,145,141,132,127,124,112,109,101,99,81,77,74,71,54,53,48,47,43,42,40,38,23,22,15,14,13,11,8,4] were screened. The GSTP1 methylation was detected in breast tumors which was associated with higher tumor grade (p=0.000),tumor stage and tumor metastasis.There was also a significant correlation between tumor stage,grade and metastasis status with sites of methylation
COI code: CIGS12_0222
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Alizadeh Shargh, Shohreh; Shahrzad Soleimani & Hamidreza Yazdi, 2012, Methylation changes in glutation S-transferase P1(GSTP1) gene promoter in human breast cancer and it’s relation to tumor prognosis., 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS12-CIGS12_0222.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Alizadeh Shargh, Shohreh; Shahrzad Soleimani & Hamidreza Yazdi, 2012)
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