Copy number variation detection using exome sequencing data
Publish place: 12th Congress of Iranian Genetics Society
Publish Year: 1391
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
CIGS12_0837
تاریخ نمایه سازی: 5 بهمن 1392
Abstract:
Copy number variation (CNV) is a significant source of human genetic diversity and it’s also known to sometimes cause diseases. CNVs are generally identified using array based approaches. However, with the development of next generation sequencing techniques there is now a great need for analysis tools that can be used to identify CNVs from sequence data. In this research, we have developed a kernel smoothing algorithm to identify CNVs based on exome sequencing data from parent-offspring trios
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Authors
Amin Z.Saffari
Department of Immunology, Genetics and Pathology, Science for Life Laboratory Uppsala, Rudbeck laboratory
Jonatan Halvardson
Department of Immunology, Genetics and Pathology, Science for Life Laboratory Uppsala, Rudbeck laboratory
Lars Feuk
Department of Immunology, Genetics and Pathology, Science for Life Laboratory Uppsala, Rudbeck laboratory