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The influence of -330 IL-2 gene polymorphism on plasma concentration of IL-2 in Iranian multiple sclerosis patients

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Year: 2012
COI code: CIGS12_0985
Paper Language: English

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Authors The influence of -330 IL-2 gene polymorphism on plasma concentration of IL-2 in Iranian multiple sclerosis patients

  Aida Sayad - Department of Biochemistry, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran
  Ablolamir Allameh - Department of Biochemistry, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
  Arezou Sayad - Department of Medical Genetics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
  Mehrdad Norouzi nia - Department of Medical Genetics, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.

Abstract:

Multiple sclerosis (MS) is a chronic neuroinflammatory demyelinating disease of the central nervous system. It is seemed cytokine genes are involved in the autoimmune disease such as MS. In this study, we assessed the influence of -330 IL-2 gene polymorphism on concentration of IL-2 in Iranian multiple sclerosis patients. One hundred MS patients and one hundred matched healthy controls was studied the RLFP-PCR method was applied to define different alleles and genotypes among individuals. Human IL-2 kit of eBioscience company was employed. Our results showed that patients discovered higher degrees of IL-2 plasma concentration than controls but in exact, only patients with -330 T/T IL-2 genotype had significant increase in amount of IL-2 plasma concentration. In conclusion, -330 T/T IL-2 genotype effect on higher plasma concentration of IL-2 in MS patients than healthy individuals.

Keywords:

multiple sclerosis, IL-2, polymorphism, genetic susceptibility

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COI code: CIGS12_0985

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Sayad, Aida; Ablolamir Allameh; Arezou Sayad & Mehrdad Norouzi nia, 2012, The influence of -330 IL-2 gene polymorphism on plasma concentration of IL-2 in Iranian multiple sclerosis patients, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS12-CIGS12_0985.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Sayad, Aida; Ablolamir Allameh; Arezou Sayad & Mehrdad Norouzi nia, 2012)
Second and more: (Sayad; Allameh; Sayad & Norouzi nia, 2012)
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Type: state university
Paper No.: 25925
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