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Investigation of association among SNPrs:12676 in CHDH gene and azoospermia in Iranian population

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Year: 2014
COI code: CIGS13_0104
Paper Language: English

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Authors Investigation of association among SNPrs:12676 in CHDH gene and azoospermia in Iranian population

Narjes Bakhtari - Tehran, ShahidBeheshti University
Masoud Sheidai - Tehran, ShahidBeheshti University
  Hamid Gurabi - Tehran, Royan Institute
Esmat Ghalkhani - Tehran, ShahidBeheshti University


Introduction: Infertility is a complex clinical problem that affect of couples. Half of these cases arise from male factors. Azoospermiais a condition in there is no sperm in semen of patient.CHDH codes the Choline dehydrogenase enzyme which acts in mitochondria and produces ATP moleculeand has a role in it,s motility. Purpose: A case-control population study was performed to:1) find the diversity among the two different populations of Iran, the North and the Center in totally 58 samples, 2) investigation the association of the SNPrs: 12676(G T) in CHDH with azoospermia in both groups. Material and methods: Two separated population of Center and North of Iran( In Royan Institute)were collected .A 243segment of the gene was amplified using PCR.all sampleswere genotyped using direct sequencing.Statistical analyses such as: Chi-squared test and Odds Ratio to investigate the association of the SNP and azoospermia, Phylogenetic trees including: Neighborhood Joining, UPGMA, Maximum Parsimony and Maximum Likelihood trees toinvestigategenetic differences among the population, AMOVA to investigate the genetic difference in populations, K-Means and STRUCTURE analysis toinvestigate of continuity versus stratification, PCOA analysis to find the relation between individuals in each population. The network in which CHDH acts was found in SWISS-Prot data base. Result: there was no significant difference among our populations which meant they were almost genetically similar. We alsofind a positive association between the SNP and azoospermiainfertility in both of underlying populations


infertility, azoospermia, Choline Dehydrogenase, genetic diversity

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COI code: CIGS13_0104

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Bakhtari, Narjes; Masoud Sheidai; Hamid Gurabi & Esmat Ghalkhani, 2014, Investigation of association among SNPrs:12676 in CHDH gene and azoospermia in Iranian population, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Bakhtari, Narjes; Masoud Sheidai; Hamid Gurabi & Esmat Ghalkhani, 2014)
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