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Evaluation of NaV1.5-related genes in Iranian Brugada Syndrome patients

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Year: 2014
COI code: CIGS13_0300
Paper Language: English

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Authors Evaluation of NaV1.5-related genes in Iranian Brugada Syndrome patients

s saber - I. M. Sechenov First Moscow state medical university, Moscow, Russia Petrovsky Russian Research Center of Surgery, RAMS, Moscow, Russia.
  m houshmand - Dept. of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
  a.f fazelifar - Shaheed Rajaei Cardiovascular, Medical & Research Center, Iran University of Medical Science,Tehran, Iran.
  m haghjoo - Shaheed Rajaei Cardiovascular, Medical & Research Center, Iran University of Medical Science,Tehran, Iran.

Abstract:

Background:Brugada syndrome (BrS) is a primary arrhythmia syndrome characterized by right precordial ST elevation and intermittent right bundle-branch block, which may cause syncope and sudden cardiac death with a normal heart. At least seventeen genes are known to be causative for BrS. SCN5A gene mutations account 15-30% of index patients. Genetic screening of other genes slightly increases the diagnostics efficiency (7-8%).Frequency of mutations in different genes can be alsovarying significantly in populations. There was no systematic screening of Iranian BrS so far.Methods: A cohort of 50 unrelated Iranian BrS patients was investigated. Standard ECG, Echocardiography and flecainide challengetest was done. Screening of all coding exons and splice sites of α and β subunits related of NaV1.5 genes (SCN5A, SCN1b, SCN2b, SCN3b and SCN4b) and genes encoding NaV1.5 interacting proteins (SNTA1, CAV3 and MOG1) were performed by PCR-based and next generation sequencing and Sanger sequencing .Results: Nine mutations in SCN5A gene were found in index patients (р.A735V, р.Q778X, р.Y1434X, p.R1193W, р.R1316X, р.del_KPQ1505-1507, р.P1506S р.S1710L and р.R1929C), No rare non-synonymous variant was found in others genes inthis study. Conclusions: According to this study, the prevalence of SCN5A-positive probands in Iranian BrS group is 18%. We did not find any mutations in β subunits related of NaV1.5 genes and genes encoding NaV1.5-interacting proteins of BrS. The genetic screening of SCN5A gene can be proposed as a diagnostic tool for Iranian BrS patients. Genetic screening of calcium and potassium channel genes is planned for the same cohort

Keywords:

SCN5A, Brugada syndrome, NaV1.5

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COI code: CIGS13_0300

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saber, s; m houshmand; a.f fazelifar & m haghjoo, 2014, Evaluation of NaV1.5-related genes in Iranian Brugada Syndrome patients, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0300.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (saber, s; m houshmand; a.f fazelifar & m haghjoo, 2014)
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