CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings
Paper
title

Associated between insertion/deletion polymorphism of MDM2 and risk of breast cancer in an Iranian population

Credit to Download: 1 | Page Numbers 8 | Abstract Views: 608
Year: 2014
COI code: CIGS13_0489
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Associated between insertion/deletion polymorphism of MDM2 and risk of breast cancer in an Iranian population

  Mohsen Omrani - Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences,Zahedan, Iran
  Mohammad Hashemi - Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences,Zahedan, Iran
  Ebrahim Eskandari-Nasab - Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences,Zahedan, Iran

Abstract:

Background: MDM2 (Murine Double Minute-2) is an oncoprotein that inhibits the P53 activity.Overexpression of MDM2 gene has been reported in several human tumors. In the present study we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism in the promoter ofMDM2 and susceptibility to breast cancer in a sample of Iranian population. Methods: This case-control study was done on 236 patients with breast cancer and 203 healthy individuals. The 40-bp ins/del polymorphism was determined by using polymerase chain reaction method.Results: The findings indicated that MDM2 ins/del variant increased the risk of breast cancer in codominant (OR=2.09, 95%CI=1.14-3.85, P=0.018, del/del vs ins/ins), dominant (OR=1.49, 95%CI=1.02-2.18, P=0.038, ins/del+del/del vs ins/ins) and recessive (OR=1.86, 95%CI=1.03-3.34, P=0.038, del/del vs ins/ins+ins/del) tested inheritance models. The del allele increased the risk of breast cancer (OR= 1.48, 95% CI=1.11-1.98, P=0.008) compared with ins allele.Conclusions: Our result revealed that 40-bp ins/del polymorphism in the promoter of MDM2 increased the risk of breast cancer in an Iranian population. Further investigations with larger sample sizes and diverse ethnicities are needed to verify our findings.

Keywords:

Breast cancer, MDM2, insertion ، deletion, polymorphism

Perma Link

https://www.civilica.com/Paper-CIGS13-CIGS13_0489.html
COI code: CIGS13_0489

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Omrani, Mohsen; Mohammad Hashemi & Ebrahim Eskandari-Nasab, 2014, Associated between insertion/deletion polymorphism of MDM2 and risk of breast cancer in an Iranian population, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0489.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Omrani, Mohsen; Mohammad Hashemi & Ebrahim Eskandari-Nasab, 2014)
Second and more: (Omrani; Hashemi & Eskandari-Nasab, 2014)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)

Scientometrics

The University/Research Center Information:
Type: Medical University
Paper No.: 1046
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.