CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings
Paper
title

Investigation of TP53 Arg72Pro and 16bp duplication polymorphisms in risk of breast cancer

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 650
Year: 2014
COI code: CIGS13_0536
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Investigation of TP53 Arg72Pro and 16bp duplication polymorphisms in risk of breast cancer

  Sahar Gohari –Lasaki - Department of Genetics , Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  Jalal Gharehsoran - Department of Genetics , Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , Department of Genetics , International Branch of Aras, Tabriz University of Medical Sciences, Tabriz, Iran
  Mojtaba ohaddes-Ardebili - Department of Genetics , Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , Department of Genetics , International Branch of Aras, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract:

TP53 is assumed as the most important tumour suppressor gene that recent reports have shown roles for its polymorphisms in breast cancer risk. Arg72Pro and PIN (+16bp) polymorphisms proposed to have effective role in structure changes of the p53.They have been inspected as risk factor for breast cancer in differentpopulations. The aim of our group was to investigate whether p53 codon 72 and PIN3 Ins16bp may be associated with anincreased riskfor breast cancer in patients originated from Eastern Azarbaijan of Iran. Genotyping was performed by PCR_RFLP method for totally 100 cases and 100 healthy women without background of any cancer. We suggest that TP53 Arg72Pro-16Del/Ins haplotype and the combined genotype are likely genetic markers contributing to susceptibility of breast cancer in regions. In this study no statistically significant differences between the genotypes and allele frequency were found for Arg72Pro and PIN3 Ins 16 bp polymorphisms between patients and controls.

Keywords:

Breast Cancer , Polymorphism, TP53 , codon 72 , PIN3 Ins16bp

Perma Link

https://www.civilica.com/Paper-CIGS13-CIGS13_0536.html
COI code: CIGS13_0536

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Gohari –Lasaki, Sahar; Jalal Gharehsoran & Mojtaba ohaddes-Ardebili, 2014, Investigation of TP53 Arg72Pro and 16bp duplication polymorphisms in risk of breast cancer, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0536.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Gohari –Lasaki, Sahar; Jalal Gharehsoran & Mojtaba ohaddes-Ardebili, 2014)
Second and more: (Gohari –Lasaki; Gharehsoran & ohaddes-Ardebili, 2014)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)

Scientometrics

The University/Research Center Information:
Type: Medical University
Paper No.: 2416
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.