Published in: 12th Congress of Iranian Genetics Society
COI code: CIGS13_0536
Paper Language: English
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Authors Investigation of TP53 Arg72Pro and 16bp duplication polymorphisms in risk of breast cancerSahar Gohari –Lasaki - Department of Genetics , Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Jalal Gharehsoran - Department of Genetics , Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , Department of Genetics , International Branch of Aras, Tabriz University of Medical Sciences, Tabriz, Iran
Mojtaba ohaddes-Ardebili - Department of Genetics , Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , Department of Genetics , International Branch of Aras, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract:TP53 is assumed as the most important tumour suppressor gene that recent reports have shown roles for its polymorphisms in breast cancer risk. Arg72Pro and PIN (+16bp) polymorphisms proposed to have effective role in structure changes of the p53.They have been inspected as risk factor for breast cancer in differentpopulations. The aim of our group was to investigate whether p53 codon 72 and PIN3 Ins16bp may be associated with anincreased riskfor breast cancer in patients originated from Eastern Azarbaijan of Iran. Genotyping was performed by PCR_RFLP method for totally 100 cases and 100 healthy women without background of any cancer. We suggest that TP53 Arg72Pro-16Del/Ins haplotype and the combined genotype are likely genetic markers contributing to susceptibility of breast cancer in regions. In this study no statistically significant differences between the genotypes and allele frequency were found for Arg72Pro and PIN3 Ins 16 bp polymorphisms between patients and controls.
Keywords:Breast Cancer , Polymorphism, TP53 , codon 72 , PIN3 Ins16bp
COI code: CIGS13_0536
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Gohari –Lasaki, Sahar; Jalal Gharehsoran & Mojtaba ohaddes-Ardebili, 2014, Investigation of TP53 Arg72Pro and 16bp duplication polymorphisms in risk of breast cancer, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0536.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Gohari –Lasaki, Sahar; Jalal Gharehsoran & Mojtaba ohaddes-Ardebili, 2014)
Second and more: (Gohari –Lasaki; Gharehsoran & ohaddes-Ardebili, 2014)
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Type: Medical University
Paper No.: 2416
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