Published in: 12th Congress of Iranian Genetics Society
COI code: CIGS13_0934
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Epigenetic modifications and human disease; a plausible prospects for epigenetic therapyYounes Aftabi - Department of Biology, Azerbaijan Shahid Madani Univesity, Tabriz, Iran
Farzaneh Sadeghi - Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
Mahnaz Sadeghi - Departments of Biology, Higher Education Institute of Rab-Rashid, Tabriz, Iran
Seyed Jalal Zargar - Department of Cell & Molecular Biology, College of Science, University of Tehran, Tehran, Iran
Abstract:Heritable changes in gene expression that do not involve coding sequence modifications are referred to as epigenetic . The study of human disease has focused on genetic mechanisms, however, many diseases, including certain genetic diseases, metabolic, autoimmune, and neurological disorders and tumors are accompanied by aberrant DNA methylation and/orhistone modification profiles. In contrast to genetic mutations, such epi-mutations are reversible. Therefore, the overwritingof epigenetic marks to modulate gene expression in a gene-specific way (Epigenetic Editing) would offer a novel approachin biomedical research to develop epigenetic interventions. Great potential lies in the development of ‘epigenetic therapies’ -several inhibitors of enzymes controlling epigenetic modifications, specifically DNA methyltransferases and histone deacetylases- have shown promising antitumorigenic effects for some malignancies. Thus, a comprehensive understanding of epigenetic mechanisms, their interactions and alterations in health and disease, has become a priority in biomedical research. Here we discuss the latest findings about the role of aberrant placement of the epigenetic marks and mutations which is involved in disease development. Furthermore, we indicate recent advances in the therapeutic modification by Epigenetic Editing
Keywords:Chromatin structure, Epigenetics, diseases, epigenetic therapy
COI code: CIGS13_0934
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Aftabi, Younes; Farzaneh Sadeghi; Mahnaz Sadeghi & Seyed Jalal Zargar, 2014, Epigenetic modifications and human disease; a plausible prospects for epigenetic therapy, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0934.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Aftabi, Younes; Farzaneh Sadeghi; Mahnaz Sadeghi & Seyed Jalal Zargar, 2014)
Second and more: (Aftabi; Sadeghi; Sadeghi & Zargar, 2014)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- ssociation of Codon 72 of P53 Gene Polymorphism with Chronic Hepatitis CVirus Infection: A Case Control Study
- Geometric Mean of 5S rRNA and MiR-16 as a Suitable Normalizer in Esophageal Cancer
- Unravelling Over-Represented Amino Acids in Protein Structure of Allergen Proteins; a Large-Scale Study
- Construction of the Recombinant Lentiviral Vector Containing Human GH1 Gene and its Expression in HEK293T Cells
- Attenuation of inflammation genes expression by Juglans regia extract in an Osteoarthritis in vitro like-model.
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.