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title

Over expression of NDUFS1 and NDUFS2 in methamphetamine addicted individuals

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Year: 2014
COI code: CIGS13_0960
Paper Language: English

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Authors Over expression of NDUFS1 and NDUFS2 in methamphetamine addicted individuals

  Arvin Haghighatfard - Department of biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  Mozhdeh Amini - Department of biology, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
  Alireza Rahimpour - Department of biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Abstract:

Methamphetamine is a neurotoxin and potent psycho-stimulant of the phenethylamine and amphetamine classes that is used to treat attention deficit hyperactivity disorder (ADHD) and obesity. Methamphetamine exists as two enantiomers, dextrorotary and levorotary. Dextromethamphetamine is a stronger central nervous system(CNS)stimulant than levomethamphetamine; however, both are addictive and produce the same toxicity symptoms at high doses. We have studied Metamphetamine affects on gene expression in individuals who are addicted to this drug and used it forseveral time in more than one year. blood samples collected from 30 addicted and 30 normal person in the same range ofage. RNA of whole blood extracted by column method kit . cDNA synthesized and expression of 300 gene investigated with microarray (Affymetrix gene chips) technique. expression of 12 gene had been affected . over expression of NDUFS1 and NDUFS2 , and decreasing of expression in 5HT2a,DRD2,DRD3,BDNF,DISC,NRG1,MAOA,bcl2,NDUFV1 andNDUFV2. Microarray results for two gene NDUFS1 and NDUFS2 confirmed by Real Time PCR syber green method andresults analyzed by SPSS and Bonferroni statistical soft wares. In our samples a significant affects of Metamphetamin on expression of several genes especially in mitochondria complex 1 subunits genes have been detected

Keywords:

methamphetamine,NDUFS1,NDUFS2,gene expression

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COI code: CIGS13_0960

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Haghighatfard, Arvin; Mozhdeh Amini & Alireza Rahimpour, 2014, Over expression of NDUFS1 and NDUFS2 in methamphetamine addicted individuals, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_0960.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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