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Bioinformatic Analysis of Homo sapiens ArfGAP with FG repeats 1 (AGFG1)

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Year: 2014
COI code: CIGS13_1131
Paper Language: English

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Authors Bioinformatic Analysis of Homo sapiens ArfGAP with FG repeats 1 (AGFG1)

Sahar Ghasemi - Behbahan Khatamolanbia University of Technology
farzaneh yazdani - Behbahan Khatamolanbia University of Technology
mahnaz vahidian - Behbahan Khatamolanbia University of Technology
nahid boveyrati - Behbahan Khatamolanbia University of Technology

Abstract:

Many steps in vesicular transport depend on a variety of GTP-binding proteins that control both the spatial and temporal aspects of membrane exchange. GTP-binding proteins regulate most processes in eukaryotic cells. They act as molecular switches, which flip between an active state with GTP boundand an inactive state with GDP bound. The Arf proteins, which are responsible for both COPI coat assembly and clathrin coat assembly at Golgi membranes. In other way FG-repeats serve as binding sites for the import receptors. They are thought to line the path through the NPCs taken by the importreceptors and their bound cargo proteins. In this study it is investigated about Homo sapiens ArfGAP with FG repeats 1 (AGFG1) using several bioinformatics methods. Results showed that local synthesis of phosphoinositides creates binding sites that trigger coat assembly and vesicle budding. In addition,monomeric GTPase help regulate ariouss tepsi nuesiculart transport, including both vesicle buddingand docking. The coat-recruitment GTPases, including sarl and the Arf proteins, regulate coat assembly and disassembly. AGFGA1 gene is located on chromosome number 2 and its protein is a nuclear protein with the probability of 47.8%.

Keywords:

Homo sapiens; AGFG1; Arf proteins; Bioinformatics

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COI code: CIGS13_1131

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Ghasemi, Sahar; farzaneh yazdani; mahnaz vahidian & nahid boveyrati, 2014, Bioinformatic Analysis of Homo sapiens ArfGAP with FG repeats 1 (AGFG1), 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_1131.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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