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Inhibin A for screening of Down syndrome in Second-Trimester

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Year: 2014
COI code: CIGS13_1193
Paper Language: English

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Authors Inhibin A for screening of Down syndrome in Second-Trimester

  Ali mohammadi - Department of genetic, East Azarbaijan Science and Research Branch, Islamic Azad University, Tabriz, Iran
  behzad mansoori - Department of immunology, Tabriz University of medical science, Tabriz, Iran
younes mirbeygi - Department of genetic, East Azarbaijan Science and Research Branch, Islamic Azad University, Tabriz, Iran


Maternal age-specific risks to provide screening protocols for Down syndrome. In the second trimester,measurement of maternal serum alpha-fetoprotein (AFP), unconjugated estriol (E3), and human chorionic gonadotropin (hCG) plus maternal age is used in a widely accepted protocol for theidentification of pregnancies at high risk for fetal Down syndrome.1–3 This triple test has a 71.3% sensitivity at a 5% false-positive rate for pregnancies in which the gestational age is established by ultrasound.4 the combination of maternal serum AFP, E3, hCG, and the βA subunit of inhibin, termedinhibin-A, can be shown to improve the sensitivity and lower the false-positive rate of the screening.5,6 The expected sensitivity for this quadruple test is 77.5% when the false-positive rate is held at 5%.5 Applied to the 1999 US population, this should achieve an 81.5% detection rate with a 6.9% falsepositiverate.7-9 The aim of this study was evaluating the efficacy of the second-trimester quadruple test (maternal serum alpha-fetoprotein, unconjugated estriol, human chorionic gonadotropin, and inhibin- A) in prenatal screening for Down syndrome in Tabriz. Martial and method This Cross - sectional study on 111 cases referred to the Tabriz’s Clinical Laboratory, alphafetoprotein, unconjugated estriol, human chorionic gonadotropin (monobind, USA) inhibin- A(Beckman coulter ,Ireland) were measured by the ELISA and electrochemiluminescence .Then the data were analyzed by SPSS13 Software. Result The mean age of the pregnant was 27.74 ± 6.1. high level of inhibin A in 45 cases(40.5 percent), lowlevel of UE3 in 24 cases (21.6 percent), low level of AFP in 30 cases (27 percent) and high level of BHCG in 36 cases (34.2 percent)were seen. The mean probability of Down syndrome incidence Tabriz pregnant is 0.00028. Conclusion The quadruple test shows a higher sensitivity and lower false-positive rate than the triple test. Relative to screening with the triple test, the use of the quadruple test should result in greater separation of theaffected and unaffected pregnancy risk distributions, and we conclude that inhibin-A should be widely available for second trimester Down syndrome screening.


Down syndrome, Inhibin A, quad test

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COI code: CIGS13_1193

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mohammadi, Ali; behzad mansoori & younes mirbeygi, 2014, Inhibin A for screening of Down syndrome in Second-Trimester, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (mohammadi, Ali; behzad mansoori & younes mirbeygi, 2014)
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