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title

Insilico study of Gag polyprotein: potential target for investigating on HIVdiagnosis and therapy

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Year: 2014
COI code: CIGS13_1200
Paper Language: English

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Authors Insilico study of Gag polyprotein: potential target for investigating on HIVdiagnosis and therapy

Zeynab Azad - Behbahan Khtamolanbia University of Technology
Elahe kamalzadeh - Behbahan Khtamolanbia University of Technology
anis nozari - Behbahan Khtamolanbia University of Technology
forough bakhtiyari - Behbahan Khtamolanbia University of Technology

Abstract:

The HIV-1 genome encodes 9 genes, comprising gag, pol, env, tat, rev, vif, vpu, vpr and nef. The gag gene encodes a polyprotein precursor whose name, Pr55Gag, is based on its molecular weight. Here, we are describing Gag-polyprotein, starting with its sequence, homology and phylogenetics. Additionally, consisting motifs and structural properties of the Gag-polyprotein were considered. Following their compartmentalization, we studied their genomics, transcriptomics, and proteomics data. We have concluded that CA or p24 peptide of Gag polyprotein has conserved domain that can be utilized for diagnosis of HIV infection. In addition, Gag polyprotein is absolutely essential for packaging the viral particles; if siRNAs or shRNAs could be designed for conserved domains of p24 then virus replication cycle would be interrupted.

Keywords:

Gag polyprotein; HIV; Insilico study; Diagnosis; Therapy

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COI code: CIGS13_1200

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Azad, Zeynab; Elahe kamalzadeh; anis nozari & forough bakhtiyari, 2014, Insilico study of Gag polyprotein: potential target for investigating on HIVdiagnosis and therapy, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_1200.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Azad, Zeynab; Elahe kamalzadeh; anis nozari & forough bakhtiyari, 2014)
Second and more: (Azad; kamalzadeh; nozari & bakhtiyari, 2014)
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