Published in: 12th Congress of Iranian Genetics Society
COI code: CIGS13_1203
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Association of HFE gene mutations with the increased risk of coronary artery disease in the Iranian populationL Saremi - Science and Research Branch Islamic AzadUniversity, Tehran, Iran
Abstract:Diabetes mellitus is a risk factor for Cardiovascular disease which is the major cause of death in type 2 diabetes. The frequency of HFE gene mutations could be elevated among type 2 diabetes patients and as a result, among CAD cases. The purpose of this study is to assess whether C282Y and H63Dmutations in the HFE gene might be associated with increased risk of CAD in type 2 diabetic patients in the Iranian population. There have been enrolled 290 unrelated individuals, divided into case and control groups. The genomic DNA was extracted from the peripheral venous blood and the genotypingof HFE gene mutations has been made using the PCR–RFLP technique. Statistical analysis were performed using SPSS 12.0 software. The data analysis revealed a significant difference between the allele frequencies of H63D and C282Y mutations among cases and controls. This genotype distributionsuggests a significant association between HFE mutations and CAD status. In conclusion our findingsprovide evidence of an association between C282Y and H63D mutations and development of CAD in diabetic patients, thus indicating that HFE mutations are genetic markers of coronary risk in the Iranian population
Keywords:Type 2 diabetes, coronary artery disease, HFE gene, H63D and C282Y mutations
COI code: CIGS13_1203
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Saremi, L, 2014, Association of HFE gene mutations with the increased risk of coronary artery disease in the Iranian population, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, https://www.civilica.com/Paper-CIGS13-CIGS13_1203.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Saremi, L, 2014)
Second and more: (Saremi, 2014)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Azad University
Paper No.: 21872
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Attenuation of inflammation genes expression by Juglans regia extract in an Osteoarthritis in vitro like-model.
- Identification of novel short tandem repeats based markers in the expressed sequence of Malus domestica Borkh.
- In silico study of anti-CCHFV effect of lactoferrin from different origin
- Optimization of DNA extraction from different tissues of a medicinal plant, Senecio vulgaris L.
- Design and construction of a new operator: A new attempt to improve protein expression under industrial condition
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.