CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings

Relationship between PPARGC1A gene polymorphisms and coronary artery disease in the Iranian population

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 399
Year: 2014
COI code: CIGS13_1204
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Relationship between PPARGC1A gene polymorphisms and coronary artery disease in the Iranian population

  L Saremi - Science and Research Branch Islamic AzadUniversity, Tehran, Iran


Type 2 diabetes increases the risk of CAD in patients with type 2 diabetes compared with nondiabetic subjects. several genetic variants considere as risk factors for CAD, including those implicated in dyslipidaemia and oxidative stress. The PPARGC1A gene considers as a key regulator of pathophysiological processes contributingto CAD. In the present study, we investigated whether the Gly482Ser polymorphism (rs8192678) increasedsusceptibility to CAD or in Iranian population and whether it was associated with clinical and metabolic parameters. A total of 290 subjects including 149 CAD patients with a history of diabetes and 149 controls were included in our study. The Gly482Ser polymorphism was genotyped using ARMS-PCR method. Based on thetype of variables, by the use of SPSS software (Statistical Package for Social Sciences Inc., Chicago, IL, USA)statistical analyses were performed. We found a significant difference in the Gly482Ser substitution between the case and control subjects in Iranian population. However no significant association was observed between Gly482Ser genotypes and physiologic variables. The results indicate that the PPARGC1A Gly482Serpolymorphism have impact on CAD susceptibility in the Iranian population. It could be concluded that this genepolymorphism may be a potential marker for increased risk of CAD in diabetic patients in clinical treatment and diagnosis


Coronary artery disease, PPARGC1A gene, CAD susceptibility

Perma Link
COI code: CIGS13_1204

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Saremi, L, 2014, Relationship between PPARGC1A gene polymorphisms and coronary artery disease in the Iranian population, 12th Congress of Iranian Genetics Society, تهران, انجمن ژنتيك ايران, the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Saremi, L, 2014)
Second and more: (Saremi, 2014)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)


The University/Research Center Information:
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper


COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.