Evaluation of Combined Status of Apoptosis-related Genes Polymorphisms in Relation to Breast Cancer RiskRunning title: Combined status of apoptosis genes polymorphisms and breast cancer risk

A single nucleotide polymorphism (SNP) in the proline-rich domain of P53, codon 72 polymorphism (a G-C exchange) can alter the structure and apoptotic role of P53 protein thereby may be causing a deficiency of FAS expression level and its tumor suppressor action. A common -1377 G-A exchange is found in FAS promoter, which can reduce the expression level of FAS. Previously, these polymorphisms have been shown to be associated with various tumor types, independently. It is probable that the investigation of combined genotypes may be more valuable than individual SNPs. In the present study, we have investigated whether the combination of the P53 and FAS polymorphisms could be responsible for genetic susceptibility to breast neoplasms. 90 breast cancer patients and 120 healthy controls entered the investigation. The javastat online statistics package software was used for statistical analysis. There was no significant discrepancy for various FAS-P53 combined genotypes between cases and control subjects in this study. Thereby, the current study showed no significant correlation between FAS-P53 polymorphisms combinations and breast cancer possibility in the examined population.

Keywords:

FAS , P53 , combined genotype , breast cancer