COI code: CIGS15_061
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Investigation expression of serum miR-320a and miR-17 as candidate biomarker in MS patients of Zanjan populationFaezeh Molaei - Department of genetics, Faculty of basic Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran.
Afsaneh Nazari - Department of genetics, Faculty of basic Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran.
Abdoreza Ghoreishi - Assistant professor of Neurology, Zanjan university of medical science.
Sanaz Mahmazi - Department of genetics, Faculty of basic Sciences, Islamic Azad University, Zanjan Branch, Zanjan, Iran.
Abstract:Objective: Multiple sclerosis (MS) is a chronic inflammatory autoimmune demyelinating disease of the central nervous system with an unknown etiology. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by binding to complementary target mRNAs and either promoting their decay or inhibiting their translation. In the human immune system, miRNAs play an important role in modulating innate and adaptive immune responses. They regulate B and T cell development and differentiation, inaddition to pro-inflammatory responses mediated by Treg cells. Dysregulation of miRNAs involved in immune responses leads to autoimmunity. In this study, we investigated the amounts of circulating miR-320a and miR-17 in plasma samples from MS patients. Methods: We investigated miR-320a and miR-17 in plasma samples of 24 MS patients and 24 healthy subjects by quantitative real-time PCR.Results: miR-320a was down- regulated in all MS patients.miR-17 expression reduced in 60% of MS patients and overexpression of miR-17 observed in 40% of patients.Conclusion: Down-regulation of miR-320a induced the overexpression of pro-inflammatory cytokines. They could activate Th1 and Th17 that are important in the pathogenesis of MS. Ectopic expression of miR-17 imparted effector-T-cell-like characteristics to Treg cells via the de-repression of genes encoding effector cytokines. MiR-17 provides a potent layer of Treg cell control. A major challenge in multiple sclerosis (MS) is to develop biomarkers that could help in understanding individual MS patients miRNAs could be a potential biomarker for diagnosis and evaluation of MS.
Keywords:Multiple Sclerosis, MicroRNAs, Autoimmunity, miR-17, miR-320a
COI code: CIGS15_061
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Molaei, Faezeh; Afsaneh Nazari; Abdoreza Ghoreishi & Sanaz Mahmazi, 2018, Investigation expression of serum miR-320a and miR-17 as candidate biomarker in MS patients of Zanjan population, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_061.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Molaei, Faezeh; Afsaneh Nazari; Abdoreza Ghoreishi & Sanaz Mahmazi, 2018)
Second and more: (Molaei; Nazari; Ghoreishi & Mahmazi, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: Azad University
Paper No.: 4271
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Study of genetic variation in chickpea (Cicer arietinum L.) genotypes based on ISSR markers and evaluation of resistance to Fusarium wilt
- Characterization of stem cells isolated from peritoneal dialysed fluid
- Association between genetic polymorphism of catalase (CAT) C-262T, Cu/Zn superoxide dismutase (SOD1) A251G and risk of Age-related macular degeneration (AMD)
- Regional variation in subclade of Leptosphaeria biglobosa
- Genetic study of external egg quality traits of native chicken of North of Iran
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.