association of the -31C˃T polymorphism in interlukin- 1B gene and the risk of gastric inflammation and peptic ulcer from Helicobacter pylori Infection

Pro-inflammatory cytokines in gastric mucosa are produced in response to H. pylori infection by inflammatory cells. Mononucleotide variation in the promoter of these cytokine genes may affect the gene expression level. It can also cause different inflammations in gastric mucosa and secretion of acid in response to the infection. Therefore, the genetic background of people and their individual differences can play a role in the development and final outcome of such diseases as peptic ulcer. Interleukin-1b (IL-1b) is a cytokine that plays a key role in moderating inflammatory response in gastric-intestinal ulcer.In the present research which is of a case-control study, the PCR-RFLP technique was used to determine the allelic and genotypic frequency of the -31C˃T polymorphism in the control and case groups and the data were analyzed by SPSS software by logistic Regression test.The results showed no significant association between the target polymorphism and gastric inflammation or peptic ulcer disease. However, environmental factors and life habits such as smoking can affect the risk of affliction and can increase this risk several times as much.There seems to be a complicated association between mononucleotide variation that can account for individual differences and one s potential of affliction with diseases. That is due to the fact that other factors can also affect the potential for a disease. These include the interaction between poly-morphisms as well as life style.

Keywords:

interleukin -1 beta , H.pylory , peptic ulcer disease , gastric inflammation.