IL-1β gene polymorphism (rs16944) in Bullous pemphigoid

Publish Year: 1397
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:

CIGS15_100

تاریخ نمایه سازی: 13 بهمن 1398

Abstract:

Objective Bullous pemphigoid (BP) is the most frequently occurring entity among autoimmune bullous skin diseases. Although the genetic determinants of BP have not been precisely elucidated, some studies have shown an association between a IL-1β polymorphism (rs16944) in BP disease susceptibility. Yet, these findings had so far not been independently replicated, and no data on a possible association of these mutations and BP in Iranian population were available.Methods The study group comprised 20 patients (69.68 ±2.9 years) with Bullous pemphigoid and 20 healthy controls (64.4 ±2.5 years). Genomic DNA was extracted from whole blood using DNG-Plus method. All individuals were genotyped for IL-1β polymorphisms using the PCR–RFLP analysis. Demographic data and clinical characteristics were analyzed for a possible effect of these factors on susceptibility to BP in patients.Results PCR-RFLP results showed that TC was most frequent genotype in both patient and control groups. CC genotype was detected in 35 % and 30% of patients and controls, respectively. Genotype TT was detected in 10% of patients and 20% of controls.There was no significant difference in genotypes of IL-1β polymorphism (rs16944) in both patients and control groups (p> 0.05).Conclusion This study did not confirm reported results of previous study concerning an association between a IL-1β polymorphism (rs16944) and BP disease in Iranian population. This results shows that the genetic predisposition to develop BP can greatly varies among different ethnic groups.

Authors

Ahmad Karimi

Department of Biology, Islamic Azad University, East Tehran Branch, Tehran, Iran

Pardis Sadat Tabatabaei Panah

Department of Biology, Islamic Azad University, East Tehran Branch, Tehran, Iran

Reza Akbarzadeh

Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Shahid Labbafi Nejad Educational Hospital, Tehran, Iran.