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Combined Effects of p53 and PAI-1 polymorphisms on the Breast Cancer Susceptibility among Iranian-Azeri Women

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Year: 2018
COI code: CIGS15_122
Paper Language: English

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Authors Combined Effects of p53 and PAI-1 polymorphisms on the Breast Cancer Susceptibility among Iranian-Azeri Women

  Nasser Pouladi, - PhD, Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran
  Mojtaba Shavali, - Department of Biology, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran

Abstract:

Backgrounds and Objectives: Breast cancer is the main cause of death especially because of this cancer in women around the world. It is a heterogeneous and multifactorial disease. According to previous reports, polymorphism in two genes; p53, which is an important tumor suppressor gene involved in wide range of cancers, and PAI-1, which is an inhibitor protein coding plasminogen involved in progression and metastasis, has been investigated.Material and Methods: In this case-control study, 200 patients and 200 healthy women in Iranian-Azeri population were investigated. At first, genomic DNA had been extracted using high salt method, then these genes had been genotyped with tetra-ARMS PCR method. Data had been analyzed with javastat online statics package and SPSS (version 22.0). Results: Genotype distribution of these polymorphisms for p53 and PAI-1 was GG=43.5%, GC=42%, CC=14.5% and 4G/5G=70.5%, 5G/5G=18.5%, 4G/4G=11%, respectively. No association between allelic frequency and genotype, individually nor in combination have been shown. Also, there was no association between combined genotype with pathological properties of cancer.Conclusion: Our results show that polymorphism of codon 72 of p53 has a significant association with breast cancer (p value<0.023). Even though there was no association in combined genotype with breast cancer in our investigated population, further studies need to be done in bigger population and other races.

Keywords:

Breast cancer, P53 gene, PAI-1 gene, Polymorphism

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COI code: CIGS15_122

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Pouladi,, Nasser & Mojtaba Shavali,, 2018, Combined Effects of p53 and PAI-1 polymorphisms on the Breast Cancer Susceptibility among Iranian-Azeri Women, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_122.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Pouladi,, Nasser & Mojtaba Shavali,, 2018)
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Type: state university
Paper No.: 2474
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