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The Role of PACER long non-coding RNA in multiple sclerosis

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Year: 2018
COI code: CIGS15_126
Paper Language: English

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Authors The Role of PACER long non-coding RNA in multiple sclerosis

  Zeinab Shirvani Farsani - Department of Cellular and Molecular Biology, Faculty of life Sciences and Technology, Shahid Beheshti University G.C., Tehran, Iran.
  Mina Rezai - Department of Cellular and Molecular Biology, Faculty of life Sciences and Technology, Shahid Beheshti University G.C., Tehran, Iran.
  Shirin Farivar - Department of Cellular and Molecular Biology, Faculty of life Sciences and Technology, Shahid Beheshti University G.C., Tehran, Iran.

Abstract:

Background: Multiple sclerosis (MS) is a chronic progressive inflammatory disease of the central nervous system (CNS). There is an interest in potential biomarkers that could provide information predicting disease activity and progression. Long non-coding RNAs (lncRNAs) have been recently reported to participate in the regulation of immune responses. Here, we examined the expression levels of lncRNA PACER (p50-associated COX-2 extragenic RNA) in PBMCs from patients with MS compared with healthy subjects.Methods: For this study, we recruited 40 patients with MS according to the revised McDonald criteria and 33 healthy subjects. The expression levels of PACER gene were examined with Real time PCR method. Results: A significant increase was observed in expression of PACER in MS patients. Moreover, we found some significant correlations between lncRNA expression levels and clinical data of MS patients.Conclusion: Our results shed further light to the inflammatory aspects of MS with emphasis to the regulatory role of this lncRNA in the physiopathology of MS. However, the specific molecular mechanisms and biological functions of this lncRNA need further study.

Keywords:

PACER, Multiple sclerosis, long non coding RNA

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COI code: CIGS15_126

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Shirvani Farsani, Zeinab; Mina Rezai & Shirin Farivar, 2018, The Role of PACER long non-coding RNA in multiple sclerosis, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_126.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Shirvani Farsani, Zeinab; Mina Rezai & Shirin Farivar, 2018)
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Type: state university
Paper No.: 16946
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