Investigation of ADGRL4(ELTD1) gene expression in breast cancer

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death among women. Breast cancer is a highly heterogeneous disease that results from the interaction of hereditary and environmental risk factors.ADGRL4 gene encoded a protein that is a G protein-coupled receptor expressed on the surface of endothelial cells and vascular smooth muscle cells that plays a role in angiogenesis.According to the previous studies , Expression of ADGRL4 was significantly increased in glioblastoma.This study aimed to evaluate the expression of ADGRL4 gene in breast cancer. Breast tumor tissues and their non-tumoral margin samples were obtained from 30 patients. Total RNA was purified with Trizol and expression of ADGRL4 was quantified using qRT-PCR. Our results showed significantly altered ADGRL4 expression in tumor tissues compared to adjacent normal tissues.

Keywords:

breast cancer , Expression , qRT-PCR