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Association of Severe Oligospermia With a Balanced Translocation t(6;22)(p12;p11) in an Infertile Male: a Case Study

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Year: 2018
COI code: CIGS15_178
Paper Language: English

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Authors Association of Severe Oligospermia With a Balanced Translocation t(6;22)(p12;p11) in an Infertile Male: a Case Study

  Naser Ajami - Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Mojtaba Hasanpour - Medical Genetics department, Boushehr University of medical sciences, Boushehr, Iran.. Mehr Medical Diagnostic Laboratory, Boushehr, Iran
Maryam Khavari - Mehr Medical Diagnostic Laboratory, Boushehr, Iran
Mohamad Reza Farzaneh - Department of pathology, Boushehr University of Medical Sciences, Boushehr, Iran

Abstract:

Objective: Infertility affects about 15 % of couples attempting pregnancy, with male factor infertility identified in roughly 20-30% of the cases. However, many aspects of male infertility are poorly understood, and many cases of male infertility are diagnosed as idiopathic. Cytogenetic analysis is becoming increasingly important for characterizing a number of causes of infertility. It has been reported that male infertility may be associated with chromosomal aberrations, which usually involve sex and autosomal chromosomes.Materials and Methods: We report a 36-year-old man with 12 years’ primary infertility and severe oligospermia. Peripheral blood lymphocytes were obtained for karyotyping, and 39 metaphases were studied by standard trypsin GTG technique. Investigation of Y-chromosome microdeletions was performed by the multiplex polymerase chain reaction (PCR) method.Result(s): An apparently unique reciprocal translocation t(6;22)(p12;p11) was found. In this study, according to our knowledge, this is the first report of t(6;22)(p12;p11) translocation in a severe oligozoospermic infertile male. No Y-chromosome microdeletions were found. Conclusion(s): Physical contact of unpaired autosomal material with sex chromosomes, which leads to spermatogenic arrest, may be one of the factors that accounts for infertility in men with autosomal abnormalities. Therefore this case supports the relationship between chromosomal aberrations with male infertility. Investigation of genetic alterations in infertile males has to be performed prior to performing any assisted reproduction technique.

Keywords:

Oligospermia, Infertility, Cytogenetic analysis, Balanced translocation

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COI code: CIGS15_178

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Ajami, Naser; Mojtaba Hasanpour; Maryam Khavari & Mohamad Reza Farzaneh, 2018, Association of Severe Oligospermia With a Balanced Translocation t(6;22)(p12;p11) in an Infertile Male: a Case Study, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_178.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Ajami, Naser; Mojtaba Hasanpour; Maryam Khavari & Mohamad Reza Farzaneh, 2018)
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Type: Medical University
Paper No.: 5461
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