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Association of Vascular Endothelial Growth Factor, (VEGF), expression with tumor grade in esophageal cancer

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Year: 2018
COI code: CIGS15_182
Paper Language: English

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Authors Association of Vascular Endothelial Growth Factor, (VEGF), expression with tumor grade in esophageal cancer

  Shabbou Bahramian - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran
  Mohammad Shafiee - Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran.Department of Medical Genetics,Faculty of Advaced Medical Technologies, Golestan University of Medical Sciences, Gorgan, Iran
  Reza Sahebi - Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences , Shahrekord, Iran- Genetic department, Babol University of Medical Science, Ganj afrooz road, Babol, Ir
Zahra roohinejad -

Abstract:

Background: Esophageal cancer is the 8th most important cancer in the world. VEGF Vascular Endothelial Growth Factor, VEGF, protein expression is potentiated in response to the hypoxic state. VEGF is upregulated in many known tumors and its expression is correlated with tumor stage and progression. VEGF gene is mutated in the different type of esophageal cancers. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. The present study examined the expression pattern of VEGF in esophageal squamous cell carcinoma (ESCC).Method: Eighty tumor tissues and margin normal tissues of ESCC cancer were collected patients who underwent surgery from the Tumor Bank of Cancer Institute, Imam Khomeini Hospital, Tehran. The gene expression level of VEGF was evaluated using quantitative RT-PCR method. PCR products were normalized to GAPDH as an internal control. All experiments were performed with two replicates. The fold-change expression was analysed by t-test. In which (P ≤ 0.05).Results: The quantitative Real-Time RT-PCR results revealed a significant upregulation of VEGF (P-value=0.0113) in tumor samples of ESCC, compared to their matched non-tumor tissues obtained from the margin of the same tumors. Moreover, our data demonstrated a meaningful upregulation of VEGF in high-grade tumor samples, in comparison to the low-grade ones (P-value=0.002).Conclusion: The elevated level of VEGF expression in tuomr associated grade may be an interesting issue for molecular targeting in esophageal cancer therapy.

Keywords:

Esophageal Squamous Cell Carcinoma (ESCC), VEGF, Tumor grade.

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COI code: CIGS15_182

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Bahramian, Shabbou; Mohammad Shafiee; Reza Sahebi & Zahra roohinejad, 2018, Association of Vascular Endothelial Growth Factor, (VEGF), expression with tumor grade in esophageal cancer, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_182.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Bahramian, Shabbou; Mohammad Shafiee; Reza Sahebi & Zahra roohinejad, 2018)
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Type: Medical University
Paper No.: 627
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