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Correlation analysis between SNHG1 and miR-195 in colorectal tumor tissues

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Year: 2018
COI code: CIGS15_207
Paper Language: English

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Authors Correlation analysis between SNHG1 and miR-195 in colorectal tumor tissues

  Niloofar Avazpour - Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  Mohammadreza Hajjari - Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Abstract:

Colorectal cancer (CRC) is one of the most common types of cancer worldwide [1]. However, the molecular mechanisms involved in CRC initiation and progression is remained to be unknown. Recent studies have shown that up to 98% of the genomic DNA is transcribed to a complicated network of non-coding transcripts such as miRNA, LncRNA [2]. Also, it has been revealed that lncRNAs, as the major regulators of gene transcriptional system, are involved in different biological processes such as cell cycle regulation and cytoplasmic transport [3]. In this report, we studied the correlation expression level of SNHG1 lncRNA and miR-195 in colorectal cancer tissue samples.Method We performed an in silico analysis on Starbase database and confirmed the results by experimental analysis of 20 pairs of CRC tissue samples through real time PCR. The correlation analysis between miR195 and SNHG1 genes was performed using SPSS v22. A P-value> 0.05 was considered as significant.Result Our findings indicates that overexpression of lncRNA SNHG1 could contribute to a decreased miR-195 expression in tumor tissues in comparison with adjacent normal tissues. A Pearson score of 0.074 indicates that these two genes could have a clinically and statistically value. The deviation of 0.05 is probably due to the small sample size of the statistical population and further investigation is needed on the large sample sizes to find a stronger correlation.Discussion Zhang et al. demonstrated miR-195 might act as a potential target of SNHG1 LncRNA [4]. As suggested by the Starbase database, miR-195 may interact with SNHG1. Since both SNHG1 and miR-195 expressions levels are altered in CRC, we suspected that SNHG1 may regulate miR-195 expressions, thereby affecting the carcinogenesis process of CRC. Our result indicated that SNHG1 and miR195 may act as potential biomarker in colorectal cancer.

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Avazpour, Niloofar & Mohammadreza Hajjari, 2018, Correlation analysis between SNHG1 and miR-195 in colorectal tumor tissues, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_207.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
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Type: state university
Paper No.: 13620
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