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Association of HLA-DQA1*0102, -DQB1*0602 haplotypes in in different genders of Khuzestan Province

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Year: 2018
COI code: CIGS15_228
Paper Language: English

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Authors Association of HLA-DQA1*0102, -DQB1*0602 haplotypes in in different genders of Khuzestan Province

  Nooshin delfan - Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
  Hamid Galehdari - Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
  Mohammad shafiei - Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
  Saieid Reza Khatami - Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
  Tahereh Seifi - Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
  Maryam Mohaghegh - Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Abstract:

Introduction: The human leukocyte antigen (HLA) system or complex is a gene complex encoding the major histocompatibility complex (MHC) proteins in humans. HLA are proteins or markers found on most cells in human body. Many studies show that MHC gene variants are associated with some diseases. This survey on Khuzestan population included the frequency of HLA haplotypes. HLA typing is used to match patients and donors for bone marrow or cord blood transplants; thus, reporting the association of HLA- DQA1*0102 and -DQB1*0602 haplotypes in normal population according to gender, were the goal of the study.Methods: This study included 242 healthy individuals without any disease. HLA-DQA1*0102, - and DQB1*0602alleles were genotyped, using the polymerase chain reaction amplification with sequence specific primers (PCR-SSP) method. The relationship of HLA alleles with gender examined. SPSS software was used for the statistical analyses. Result: DQB1*0602+-DQA1*0102+ as a two allelic haplotype showed no meaningful association with females compare with males (47.82% vs. 38.88%, p = 0.338, OR = 1.440 [95% CI = 0.681-3.046]). Conclusion: The study on resident in southwest of Iran gives some information about the HLA haplotype that has high frequency in both genders of this population. As DQB1*0602+-DQA1*0102+ haplotype has association with susceptibility to autoimmune diseases like MS, in some population; so, having high frequency of this haplotype may put the population in danger.

Keywords:

HLA-DQA1*0102, HLA-DQB1*0602, Haplotype; PCR-SSP; Iran.

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COI code: CIGS15_228

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delfan, Nooshin; Hamid Galehdari; Mohammad shafiei; Saieid Reza Khatami; Tahereh Seifi & Maryam Mohaghegh, 2018, Association of HLA-DQA1*0102, -DQB1*0602 haplotypes in in different genders of Khuzestan Province, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_228.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (delfan, Nooshin; Hamid Galehdari; Mohammad shafiei; Saieid Reza Khatami; Tahereh Seifi & Maryam Mohaghegh, 2018)
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Paper No.: 13648
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