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Assessment of the chromosome aneuploeidy in oligoteratospermia (OT) and normozoospermia using FISH technique

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Year: 2018
COI code: CIGS15_398
Paper Language: English

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Authors Assessment of the chromosome aneuploeidy in oligoteratospermia (OT) and normozoospermia using FISH technique

  Mahsa Nasr -Esfahani - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Biology, payame noor university, Taft, Yazd, Iran
  Fateme Montazeri - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.. Department of Biology, Yazd university of Science and Art, Yazd, Iran
  Fateme Daneshmand - Department of Biology, payame noor university, Taft, Yazd, Iran
  Seyed Mehdi Kalantar - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
  Mahya Rajabi - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.. Department of Biology, Yazd university of Science and Art, Yazd, Iran

Abstract:

Background: Infertility is one of the major psychological, economic and social problems in the human society that involves approximately 15% of couples in childbearing years. Although the role of male infertility factors has declined in recent years, but still a major part of infertility is related to the defects of the semen. since nowadays intra cytoplasmic sperm injection (ICSI) is frequently recommended, it is essential to inform them about risk of aneuploidy in their embryo. Objective: To investigate the prevalence of sperm autosome and sex chromosome aneuploeidy in oligoteratospermia (OT) and normozoospermia.Material and Methods: The study include 10 infertile oligoteratospermic men in test and 10 fertile normozoospermic men in control group. We used multi-color FISH probes for chromosomes 13,18,21, X and Y based on the frequency of them in the most reported aneuploidies. moreover, we used standard scoring criteria and a min of 30 sperm for each case to evaluating chromosomal aneuploidies.Result and Conclusion: The overall aneuploidies both in autosome and sex chromosome was higher in OT than the one detected in normozoospermia group (p<0.05). the molecular cytogenetic analysis allows the assessment of sperm aneuploidy rate and increased risk for reproduction failure. Therefore, make it possible an informed counseling for patients and in this regard, preimplantation and prenatal genetic diagnosis/screening are available.

Keywords:

Male infertility, Oligoteratospermia (OT), FISH, Aneuploidy

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COI code: CIGS15_398

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Nasr -Esfahani, Mahsa; Fateme Montazeri; Fateme Daneshmand; Seyed Mehdi Kalantar & Mahya Rajabi, 2018, Assessment of the chromosome aneuploeidy in oligoteratospermia (OT) and normozoospermia using FISH technique, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_398.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Nasr -Esfahani, Mahsa; Fateme Montazeri; Fateme Daneshmand; Seyed Mehdi Kalantar & Mahya Rajabi, 2018)
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Type: Payame Noor University
Paper No.: 46417
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