Evaluation of TBL1XR1 gene expression in breast cancer

Breast cancer is one of the most common cancers in women.Breast cancer is a highly heterogeneous disease that progressive accumulation of genetic and epigenetic changes occurs in breast cancer cells.TBL1XR1 gene is a member of WD-40 repeat genes family and the protein encoded by this gene is involved in the transcription and activation of transcription factors.According to the previous studies ,TBL1XR1 expression upregulation have been illustrated in different cancers.This study aimed to evaluate the expression of TBL1XR1 gene in breast cancer. Breast tumor tissues and their non-tumoral margin samples were obtained from 30 patients .Total RNA was purified with Trizol and expression of TBL1XR1 was quantified using qRT-PCR. qRT-PCR results indicated the significant changes in TBL1XR1 expression in tumor tissues compared with margin tissues.

Keywords:

breast cancer , Expression , qRT-PCR