Association rs6983267 polymorphism in lncRNA CCAT2 with gastric cancer susceptibility in Iranian population

Background: Globally, gastric cancer as one of the leading cause of death, can be affected by both genetic and environmental factors. According to the Iranian Ministry of Health and Medical Educations reports, 50% of all types of cancers in Iran are related to gastrointestinal and liver cancers with gastric cancer contributing to approximately 30% of them. Accumulating evidence suggests that non-coding regions of genome play a key role in cancer susceptibility and there are strong associations between many of (SNPs) single-nucleotide polymorphisms located on these regions with different types of cancers, while these SNPs may have association in one ethnic population the outcome is not extendable globally. Colon cancer-associated transcription 2 (CCAT2), a long non-coding RNA within a gene-free region on 8q24, encompasses the SNP rs6983267 which has been implicated in predisposition to many cancers. Therefore, we studied the role of rs6983267 in gastric cancer predisposition in Iranian population.Method: In present case-control study, the rs6983267 SNP of the genomic DNA samples extracted from blood of 48 patients diagnosed with gastric cancer and 54 healthy controls, was investigated. Genotyping was performed using Taqman method.Result: Hardy-Weinberg equilibrium was conducted with chi-square test in control group, it showed that the genotype distribution of rs6983267 was in equilibrium, (p <0.05, X2 = 0.96), but the genotype frequencies of rs6983267 in healthy controls were not different from those in patients (p > 0.05).Conclusion: No association was observed between rs6983267 and risk of gastric cancer, however, more studies are required in a larger population.

Keywords:

SNP , gastric cancer , rs6983267.