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Comparing the expression level of circulating miR-93 and miRNA-21 in PCOs and healthy women

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Year: 2018
COI code: CIGS15_579
Paper Language: English

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Authors Comparing the expression level of circulating miR-93 and miRNA-21 in PCOs and healthy women

  Amir Akbari-Moghadam - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.. Department of Biology, Yazd university of Science and Art, Yazd, Iran
  Fateme Hajipour - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.. Department of Biology, Yazd university of Science and Art, Yazd, Iran
  Fateme Montazeri - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.. Department of Biology, Yazd university of Science and Art, Yazd, Iran
  Seyed Mohsen Miresmaeili - Department of Biology, Yazd university of Science and Art, Yazd, Iran
  Seyed Mehdi Kalantar - Recurrent Abortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract:

Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine and metabolic disorders in premenopausal women from Iran. PCOS is currently defined as a mainly hyper androgenic disorder with a constellation of symptoms include clinical and/or biochemical hyper androgenism together with ovulatory dysfunction and/or polycystic ovarian morphology. PCOS has been associated with metabolic disorders, including insulin resistance, obesity and diabetes. MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). Objective: The objective was to determine if miRNA-93 and miRNA-21 are differentially expressed in the circulation of women with PCOS compared to age matched healthy women. Material and Methods: A case-control study was performed between women with PCOS (n = 10) and age matched controls (n = 10). Total RNA extraction from plasma and cDNA synthesis done using commercial kits. The expression of miRNA-93 and miRNA-21 and Snord miRNA as reference gene was evaluated by Real Time PCR.Result and Conclusion: The expression level of both miRNA-93 and miRNA-21 were significantly increased in PCOs relative to the control group. Despite significant relation between miRNA and serum level of AMH, there was no correlation of understudied miRNA with serum level of other reproductive hormone include FSH and estradiol. The result suggesting that miR-93 and miRNA-21 could be an efficient biomarkers for diagnosis of PCOS.

Keywords:

Real Time PCR, polycystic ovary syndrome (PCOS), microRNA, biomarker, reproductive hormone

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COI code: CIGS15_579

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Akbari-Moghadam, Amir; Fateme Hajipour; Fateme Montazeri; Seyed Mohsen Miresmaeili & Seyed Mehdi Kalantar, 2018, Comparing the expression level of circulating miR-93 and miRNA-21 in PCOs and healthy women, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_579.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Akbari-Moghadam, Amir; Fateme Hajipour; Fateme Montazeri; Seyed Mohsen Miresmaeili & Seyed Mehdi Kalantar, 2018)
Second and more: (Akbari-Moghadam; Hajipour; Montazeri; Miresmaeili & Kalantar, 2018)
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Type: state university
Paper No.: 11155
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