COI code: CIGS15_580
Paper Language: English
How to Download This Paper
For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.
Authors Association of FBXO40 rs527341033 Polymorphism and Susceptibility to Autism in Northern IranAlireza Sarkar Lotfabadi - Department of biology, Faculty of Sciences, University of Guilan, Rasht, Iran
Sina Ramezani, - Department of biology, Faculty of Sciences, University of Guilan, Rasht, Iran
Farhad Mashayekhi, - Department of biology, Faculty of Sciences, University of Guilan, Rasht, Iran
Laleh mirzanejad, - Department of biology, Faculty of Sciences, University of Guilan, Rasht, Iran
S. Shirin Shahangian, - Department of biology, Faculty of Sciences, University of Guilan, Rasht, Iran
Elham Bidabadi - Department of biology, Faculty of Sciences, University of Guilan, Rasht, Iran
Abstract:Autism is a childhood neuropsychiatric disorder which is highly heritable and characterized by presence of repetitive and restricted behavior or interest and disability in social communication. Over the past two decades, the prevalence of autism spectrum disorders (ASDs) has shown an incredible rise; the spread mean has been reported as 0.62% globally. Studying monozygotic twins revealed that autism heritability is 60% to 90% confirming that genetic factors play important roles in autism pathogenesis. According to a genome-wide study, an association between FBXO40 Copy Number Variations (CNVs) and Autism was found. The human FBXO40 gene expresses a member of F-box proteins which is marked as component of SCF (Skp1-Cullin1-F-box) E3 ubiquitin complexes. The Ubiquitin proteasome system (UPS) takes part in regulation of synaptic function such as pre-synaptic neurotransmission, apical dendrite outgrowth and synapse elimination and formation. The UPS also plays role in regulating social interactions and behaviors. The Ubiquitin-proteasome pathway causes proteolysis which affects the natural function of brain resulting neurodegenerative diseases. Here, we investigated whether FBXO40 rs527341033 polymorphism affects the susceptibility to Autism.This study included 60 autistic patients and 60 control cases. The genomic DNA was extracted from peripheral blood using a GPP solution kit. Tetra-primer ARMS-PCR method was applied for genotyping of FBXO40 rs527341033.An obvious difference was found in both allele frequencies and genotype distributions of the rs527341033 SNP between patients and control group. The results indicated that there is an association between the incidence of autism and FBXO40 rs527341033 in northern Iran.
COI code: CIGS15_580
how to cite to this paper:If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Sarkar Lotfabadi, Alireza; Sina Ramezani,; Farhad Mashayekhi,; Laleh mirzanejad,; S. Shirin Shahangian, & Elham Bidabadi, 2018, Association of FBXO40 rs527341033 Polymorphism and Susceptibility to Autism in Northern Iran, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_580.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Sarkar Lotfabadi, Alireza; Sina Ramezani,; Farhad Mashayekhi,; Laleh mirzanejad,; S. Shirin Shahangian, & Elham Bidabadi, 2018)
Second and more: (Sarkar Lotfabadi; Ramezani,; Mashayekhi,; mirzanejad,; Shahangian, & Bidabadi, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)
The University/Research Center Information:
Type: state university
Paper No.: 11373
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.
Research Info Management
Export Citation info of this paper to research management softwares
New Related Papers
- Genetic parameter estimation and model selection for hot carcass weight in matebele goat
- Survey for incidence and severity of bacterial blight of cotton caused by Xanthomonas axonopodis pv. malvacearum in different districts of Marathwada region
- Effects of aqueous crude leaf extract of senecio biafrae on the histology of the frontal cortex, kidney, liver and testis of male sprague dawley rats
- Histological study of the effects of oral administration of datura metel on the visual system of male wistar rats
- Floristics and structure of fallow vegetation
The Above articles are recently indexed in the related subjects
Iran Scientific Advertisment Netword
Share this paper
WHAT IS COI?
COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.