CIVILICA We Respect the Science
Publisher of Iranian Journals and Conference Proceedings
Paper
title

Biosynthesis and evaluation of anti-cancer effects of nanoliposome system containing essential oil of Ducrosia anethifolia (DC.) Boiss

Credit to Download: 0 | Page Numbers 1 | Abstract Views: 54
Year: 2018
COI code: CIGS15_599
Paper Language: English

How to Download This Paper

For Downloading the Fulltext of CIVILICA papers please visit the orginal Persian Section of website.

Authors Biosynthesis and evaluation of anti-cancer effects of nanoliposome system containing essential oil of Ducrosia anethifolia (DC.) Boiss

  Shahrzad Salari - MSc student of Biotechnology at Shahid Bahonar University of Kerman, Kerman, Iran.
  Shahram Pourseyedi - Associate Professor of Biotechnology, Shahid Bahonar University of Kerman, Kerman, Iran.
  Azadeh Lohrasbi Nejad - Assistant Professor of Biotechnology Department of Shahid Bahonar University of Kerman, Kerman, Iran.

Abstract:

Introduction. The plant Ducrosia anethifolia (DC.) Boiss, is native to Iran and its essential oil has cytotoxic effects. However herbal extracts have limited application due to their instability and being prone to oxidation. Nanoliposomes are spherical lipid bilayers which can encapsulate various active compounds including antibodies, proteins and aptamers and can facilitate medication delivery due to their resemblance to the cell membrane. The goal of this study was to develop nanoliposomal carriers of Ducrosia essential oil for use in biodrug delivery systems. Methods. The Ducrosia anethifolia (DC.) Boiss essential oil was first extracted and then gas chromatography and mass spectrometry were used to identify the extracted compounds. Thin-film hydration method was then used to create small liposomes loaded with the extract. The lipid phasewas prepared with L-alpha phosphatidylethanolamine dioleoyl, cholesteryl hemisuccinate and the essential oil. Finally, the cell toxicity of liposomal and free essential oil was compared on MCF7 cell line. Results. The employed methodology produced nanoliposomes measuring 269.8 nm in size with 100% frequency and polydisparity index of 0.507. Cell toxicity assay showed 60% increase in cancer cell death with liposomal essential oil. Conclusion. In this study, nanoliposomes containing Ducrosia anethifolia (DC.) Boiss essential oil were produced. Cell toxicity assay showed increased cancer cell death of liposomal essential oil compared to the free essential oil.

Keywords:

Nanoliposomes; Drug delivery; Essential oil; Ducrosia anethifolia (DC.) Boiss and MCF7.

Perma Link

https://www.civilica.com/Paper-CIGS15-CIGS15_599.html
COI code: CIGS15_599

how to cite to this paper:

If you want to refer to this article in your research, you can easily use the following in the resources and references section:
Salari, Shahrzad; Shahram Pourseyedi & Azadeh Lohrasbi Nejad, 2018, Biosynthesis and evaluation of anti-cancer effects of nanoliposome system containing essential oil of Ducrosia anethifolia (DC.) Boiss, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_599.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Salari, Shahrzad; Shahram Pourseyedi & Azadeh Lohrasbi Nejad, 2018)
Second and more: (Salari; Pourseyedi & Lohrasbi Nejad, 2018)
For a complete overview of how to citation please review the following CIVILICA Guide (Citation)

Scientometrics

The University/Research Center Information:
Type: state university
Paper No.: 14935
in University Ranking and Scientometrics the Iranian universities and research centers are evaluated based on scientific papers.

Research Info Management

Export Citation info of this paper to research management softwares

New Related Papers

Iran Scientific Advertisment Netword

Share this paper

WHAT IS COI?

COI is a national code dedicated to all Iranian Conference and Journal Papers. the COI of each paper can be verified online.