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title

Alternative Splicing of EXT1 Gene in Breast Cancer cells

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Year: 2018
COI code: CIGS15_640
Paper Language: English

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Authors Alternative Splicing of EXT1 Gene in Breast Cancer cells

  Saba Abbassioun - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran
  Nasim Ghorbanmehr - Department of Biotechnology, Alzahra University, Tehran, Iran
  Seyed Javad Mowla - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

Abstract:

Breast cancer is the most commonly diagnosed cancer and the fifth leading cause of cancer-death in women. Since the peak incidence age of Iranian women is a decade younger than that of the word, it is necessary to elucidate the mechanisms involved in the tumorgenesis of breast cancer and discover novel diagnostics markers, specific for Iranian population. The EXT1 gene is located in 8q24.11 and its only protein coding transcript encodes exostosinglycosyltransferase1 which has a vital role in intercellular connections. It has been suggested both tumor promoting and tumor suppressor role for the gene. Due to its 48.13% amplification in breast cancer, investigation of its alternatively spliced variants is important. Here, we are reporting the existence of some alternatively spliced form of the gene, with potential involvement in breast tissue tumorihgenesis.

Keywords:

Breast cancer, EXT1 gene, alternatively spliced variants

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COI code: CIGS15_640

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Abbassioun, Saba; Nasim Ghorbanmehr & Seyed Javad Mowla, 2018, Alternative Splicing of EXT1 Gene in Breast Cancer cells, The Third International and 15th National Genetics Congress, تهران, انجمن علمي ژنتيك ايران, https://www.civilica.com/Paper-CIGS15-CIGS15_640.htmlInside the text, wherever referred to or an achievement of this article is mentioned, after mentioning the article, inside the parental, the following specifications are written.
First Time: (Abbassioun, Saba; Nasim Ghorbanmehr & Seyed Javad Mowla, 2018)
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Type: state university
Paper No.: 25732
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