Antibacterial Effect of New Series of Methane Aminated 1,3,4-Oxadiazol derivetives against Methicillin-resistant Staphylococcus aureus

Background: Staphylococcus aureus in the acquisition of resistance to first-line antistaphylococcal drugs, especially β-lactams [(Methicillin-resistant Staphylococcus aureusstrains)], glycopeptides [vancomycin-intermediate S. aureus (VISA)] and vancomycin, is highly challenging [1] hence, there is an urgent need for new antibiotics against these S. aureus strains. For this reason, searching for new and more e?ective antibacterial agents with lack of side e?ects agent is essential. Compounds containing 1,3,4-oxadiazole rings have a broad biological activity spectrum including antibacterial , antifungal , analgesic , antiinflammatory, antiviral, anticancer, antihypertensive, anticonvulsant, and anti-diabetic properties [2]. Therefore, the present study seeks to investigate the antibacterial effects of new oxadiazole derivatives against this major pathogens. Method: In the present research synthesis and evaluation for antibacterial activity of a new series of 5-aryl-(1,3,4oxadiazol-2-yl) (pyridine-2yl) Methenamine derivatives were described. The compounds were characterized by IR, NMR, and mass spectroscopy. All the synthesized compounds were screened for their antimicrobial activity against Methicillin-resistant Staphylococcus aureus ATCC 700698. The broth macrodilution and agar well diffusion methods were used for determination of inhibition zoom (IZ) and minimum inhibitory concentration (MIC) during preliminary evaluation of antimicrobial activity. Results and Discution: The result show that zoon inhibition of new series of 1,3,4oxadiazolderivatives was around 18± 0.56 mm. Based on the results obtained, it can be concluded that synthesized oxadiazole derivatives can be effective compounds to Fight against Methicillinresistant Staphylococcus aureus strains. Therefore, to further studies, Researchs should be conducted in vivo Situation. Conclusions: 5-aryl-(1,3,4oxadiazol-2-yl) (pyridine-2yl) Methenamine derivatives exhibited promising antibacterial activity against Methicillin-resistant Staphylococcus aureus.

Keywords:

Antibacterial , Methicillin-resistant Staphylococcus aureus , 1 , 3 , 4oxadiazol